Tissue factor - A receptor involved in the control of cellular properties, including angiogenesis

J. Chen, A. Bierhaus, S. Schiekofer, M. Andrassy, B. Chen, David Stern, P. P. Nawroth

Research output: Contribution to journalArticle

107 Citations (Scopus)

Abstract

Tissue factor (TF), the major initiator of blood coagulation, serves as a regulator of angiogenesis, tumor growth and metastasis. In several models, TF expression mediates upregulation of the proangiogenic vascular endothelial growth factor (VEGF) that can directly act on endothelial cells to promote vessel formation. This occurs through ligand binding, activation of signaling cascades, signal transduction and alteration of growth factor expression and is mediated by both, coagulation-dependent and -independent pathways. Depending on the cell type and the biological settings. TF seems to affect cellular properties through (i) factor VIIa (FVIIa)-dependent proteolysis of factor Xa (FXa) and thrombin and subsequent activation of proteinase activated receptor (PAR) -1 and PAR-2, (ii) through direct FVIIa signaling and mitogen activated protein (MAP) kinase activation, that is conferred by a not yet identified receptor, (iii) through interaction of FVII(a) proteolytic activity and signaling of the cytoplasmic domain and (iv) through cytoplasmic signaling independent of ligand binding. The role of phosphorylation of the cytoplasmic domain and the pathways controlling phosphorylation of TF remain poorly understood.

Original languageEnglish (US)
Pages (from-to)334-345
Number of pages12
JournalThrombosis and Haemostasis
Volume86
Issue number1
StatePublished - Jul 31 2001
Externally publishedYes

Fingerprint

Thromboplastin
Factor VIIa
Phosphorylation
PAR-2 Receptor
PAR-1 Receptor
Ligands
Factor Xa
Blood Coagulation
Mitogen-Activated Protein Kinases
Thrombin
Vascular Endothelial Growth Factor A
Proteolysis
Signal Transduction
Intercellular Signaling Peptides and Proteins
Up-Regulation
Endothelial Cells
Neoplasm Metastasis
Growth
Neoplasms

All Science Journal Classification (ASJC) codes

  • Hematology

Cite this

Chen, J., Bierhaus, A., Schiekofer, S., Andrassy, M., Chen, B., Stern, D., & Nawroth, P. P. (2001). Tissue factor - A receptor involved in the control of cellular properties, including angiogenesis. Thrombosis and Haemostasis, 86(1), 334-345.

Tissue factor - A receptor involved in the control of cellular properties, including angiogenesis. / Chen, J.; Bierhaus, A.; Schiekofer, S.; Andrassy, M.; Chen, B.; Stern, David; Nawroth, P. P.

In: Thrombosis and Haemostasis, Vol. 86, No. 1, 31.07.2001, p. 334-345.

Research output: Contribution to journalArticle

Chen, J, Bierhaus, A, Schiekofer, S, Andrassy, M, Chen, B, Stern, D & Nawroth, PP 2001, 'Tissue factor - A receptor involved in the control of cellular properties, including angiogenesis', Thrombosis and Haemostasis, vol. 86, no. 1, pp. 334-345.
Chen J, Bierhaus A, Schiekofer S, Andrassy M, Chen B, Stern D et al. Tissue factor - A receptor involved in the control of cellular properties, including angiogenesis. Thrombosis and Haemostasis. 2001 Jul 31;86(1):334-345.
Chen, J. ; Bierhaus, A. ; Schiekofer, S. ; Andrassy, M. ; Chen, B. ; Stern, David ; Nawroth, P. P. / Tissue factor - A receptor involved in the control of cellular properties, including angiogenesis. In: Thrombosis and Haemostasis. 2001 ; Vol. 86, No. 1. pp. 334-345.
@article{3b398829fc2a4e33b513a272ab684fe7,
title = "Tissue factor - A receptor involved in the control of cellular properties, including angiogenesis",
abstract = "Tissue factor (TF), the major initiator of blood coagulation, serves as a regulator of angiogenesis, tumor growth and metastasis. In several models, TF expression mediates upregulation of the proangiogenic vascular endothelial growth factor (VEGF) that can directly act on endothelial cells to promote vessel formation. This occurs through ligand binding, activation of signaling cascades, signal transduction and alteration of growth factor expression and is mediated by both, coagulation-dependent and -independent pathways. Depending on the cell type and the biological settings. TF seems to affect cellular properties through (i) factor VIIa (FVIIa)-dependent proteolysis of factor Xa (FXa) and thrombin and subsequent activation of proteinase activated receptor (PAR) -1 and PAR-2, (ii) through direct FVIIa signaling and mitogen activated protein (MAP) kinase activation, that is conferred by a not yet identified receptor, (iii) through interaction of FVII(a) proteolytic activity and signaling of the cytoplasmic domain and (iv) through cytoplasmic signaling independent of ligand binding. The role of phosphorylation of the cytoplasmic domain and the pathways controlling phosphorylation of TF remain poorly understood.",
author = "J. Chen and A. Bierhaus and S. Schiekofer and M. Andrassy and B. Chen and David Stern and Nawroth, {P. P.}",
year = "2001",
month = "7",
day = "31",
language = "English (US)",
volume = "86",
pages = "334--345",
journal = "Thrombosis and Haemostasis",
issn = "0340-6245",
publisher = "Schattauer GmbH",
number = "1",

}

TY - JOUR

T1 - Tissue factor - A receptor involved in the control of cellular properties, including angiogenesis

AU - Chen, J.

AU - Bierhaus, A.

AU - Schiekofer, S.

AU - Andrassy, M.

AU - Chen, B.

AU - Stern, David

AU - Nawroth, P. P.

PY - 2001/7/31

Y1 - 2001/7/31

N2 - Tissue factor (TF), the major initiator of blood coagulation, serves as a regulator of angiogenesis, tumor growth and metastasis. In several models, TF expression mediates upregulation of the proangiogenic vascular endothelial growth factor (VEGF) that can directly act on endothelial cells to promote vessel formation. This occurs through ligand binding, activation of signaling cascades, signal transduction and alteration of growth factor expression and is mediated by both, coagulation-dependent and -independent pathways. Depending on the cell type and the biological settings. TF seems to affect cellular properties through (i) factor VIIa (FVIIa)-dependent proteolysis of factor Xa (FXa) and thrombin and subsequent activation of proteinase activated receptor (PAR) -1 and PAR-2, (ii) through direct FVIIa signaling and mitogen activated protein (MAP) kinase activation, that is conferred by a not yet identified receptor, (iii) through interaction of FVII(a) proteolytic activity and signaling of the cytoplasmic domain and (iv) through cytoplasmic signaling independent of ligand binding. The role of phosphorylation of the cytoplasmic domain and the pathways controlling phosphorylation of TF remain poorly understood.

AB - Tissue factor (TF), the major initiator of blood coagulation, serves as a regulator of angiogenesis, tumor growth and metastasis. In several models, TF expression mediates upregulation of the proangiogenic vascular endothelial growth factor (VEGF) that can directly act on endothelial cells to promote vessel formation. This occurs through ligand binding, activation of signaling cascades, signal transduction and alteration of growth factor expression and is mediated by both, coagulation-dependent and -independent pathways. Depending on the cell type and the biological settings. TF seems to affect cellular properties through (i) factor VIIa (FVIIa)-dependent proteolysis of factor Xa (FXa) and thrombin and subsequent activation of proteinase activated receptor (PAR) -1 and PAR-2, (ii) through direct FVIIa signaling and mitogen activated protein (MAP) kinase activation, that is conferred by a not yet identified receptor, (iii) through interaction of FVII(a) proteolytic activity and signaling of the cytoplasmic domain and (iv) through cytoplasmic signaling independent of ligand binding. The role of phosphorylation of the cytoplasmic domain and the pathways controlling phosphorylation of TF remain poorly understood.

UR - http://www.scopus.com/inward/record.url?scp=0034911743&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034911743&partnerID=8YFLogxK

M3 - Article

VL - 86

SP - 334

EP - 345

JO - Thrombosis and Haemostasis

JF - Thrombosis and Haemostasis

SN - 0340-6245

IS - 1

ER -