Tissue factor as a link between wounding and tissue repair

Jiang Chen, Michael Kasper, Tobias Heck, Katsumi Nakagawa, Per M. Humpert, Ling Bai, Gang Wu, Youming Zhang, Thomas Luther, Martin Andrassy, Stephan Schiekofer, Andreas Hamann, Michael Morcos, Baoshen Chen, David Stern, Peter P. Nawroth, Angelika Bierhaus

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

The initial phase of wound repair involves inflammation, induction of tissue factor (TF), formation of a fibrin matrix, and growth of new smooth muscle actin (α-SMA)-positive vessels. In diabetes, TF induction in response to cutaneous wounding, which ordinarily precedes increased expression of vascular endothelial growth factor (VEGF) and α-SMA transcription, is diminished, though not to a degree causing excessive local bleeding. Enhanced TF expression in wounds of diabetic mice caused by somatic TF gene transfer increased VEGF transcription and translation and, subsequently, enhanced formation of new blood vessels and elevated blood flow. Furthermore, increased levels of TF in wounds of diabetic mice enhanced wound healing; the time to achieve 50% wound closure was reduced from 5.5 days in untreated diabetic mice to 4.1 days in animals undergoing TF gene transfer (this was not statistically different from wound closure in nondiabetic mice). Thus, cutaneous wounds in diabetic mice display a relative deficiency of TF compared with nondiabetic controls, and this contributes to delayed wound repair. These data establish TF expression as an important link between the early inflammatory response to cutaneous wounding and reparative processes.

Original languageEnglish (US)
Pages (from-to)2143-2154
Number of pages12
JournalDiabetes
Volume54
Issue number7
DOIs
StatePublished - Jul 1 2005
Externally publishedYes

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Thromboplastin
Wounds and Injuries
Skin
Vascular Endothelial Growth Factor A
Fibrin
Wound Healing
Genes
Smooth Muscle
Blood Vessels
Actins
Hemorrhage
Inflammation
Growth

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Chen, J., Kasper, M., Heck, T., Nakagawa, K., Humpert, P. M., Bai, L., ... Bierhaus, A. (2005). Tissue factor as a link between wounding and tissue repair. Diabetes, 54(7), 2143-2154. https://doi.org/10.2337/diabetes.54.7.2143

Tissue factor as a link between wounding and tissue repair. / Chen, Jiang; Kasper, Michael; Heck, Tobias; Nakagawa, Katsumi; Humpert, Per M.; Bai, Ling; Wu, Gang; Zhang, Youming; Luther, Thomas; Andrassy, Martin; Schiekofer, Stephan; Hamann, Andreas; Morcos, Michael; Chen, Baoshen; Stern, David; Nawroth, Peter P.; Bierhaus, Angelika.

In: Diabetes, Vol. 54, No. 7, 01.07.2005, p. 2143-2154.

Research output: Contribution to journalArticle

Chen, J, Kasper, M, Heck, T, Nakagawa, K, Humpert, PM, Bai, L, Wu, G, Zhang, Y, Luther, T, Andrassy, M, Schiekofer, S, Hamann, A, Morcos, M, Chen, B, Stern, D, Nawroth, PP & Bierhaus, A 2005, 'Tissue factor as a link between wounding and tissue repair', Diabetes, vol. 54, no. 7, pp. 2143-2154. https://doi.org/10.2337/diabetes.54.7.2143
Chen J, Kasper M, Heck T, Nakagawa K, Humpert PM, Bai L et al. Tissue factor as a link between wounding and tissue repair. Diabetes. 2005 Jul 1;54(7):2143-2154. https://doi.org/10.2337/diabetes.54.7.2143
Chen, Jiang ; Kasper, Michael ; Heck, Tobias ; Nakagawa, Katsumi ; Humpert, Per M. ; Bai, Ling ; Wu, Gang ; Zhang, Youming ; Luther, Thomas ; Andrassy, Martin ; Schiekofer, Stephan ; Hamann, Andreas ; Morcos, Michael ; Chen, Baoshen ; Stern, David ; Nawroth, Peter P. ; Bierhaus, Angelika. / Tissue factor as a link between wounding and tissue repair. In: Diabetes. 2005 ; Vol. 54, No. 7. pp. 2143-2154.
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