Tissue-specific effects of loss of estrogen during menopause and aging

Korinna Wend, Peter Wend, Susan Miranda

Research output: Contribution to journalReview article

51 Citations (Scopus)

Abstract

The roles of estrogens have been best studied in the breast, breast cancers, and in the female reproductive tract. However, estrogens have important functions in almost every tissue in the body. Recent clinical trials such as the Women's Health Initiative have highlighted both the importance of estrogens and how little we know about the molecular mechanism of estrogens in these other tissues. In this review, we illustrate the diverse functions of estrogens in the bone, adipose tissue, skin, hair, brain, skeletal muscle and cardiovascular system, and how the loss of estrogens during aging affects these tissues. Early transcriptional targets of estrogen are reviewed in each tissue. We also describe the tissue-specific effects of selective estrogen receptor modulators (SERMs) used for the treatment of breast cancers and postmenopausal symptoms.

Original languageEnglish (US)
Article numberArticle 19
JournalFrontiers in Endocrinology
Volume3
Issue numberFEB
DOIs
StatePublished - Dec 1 2012

Fingerprint

Menopause
Estrogens
Breast Neoplasms
Selective Estrogen Receptor Modulators
Women's Health
Cardiovascular System
Hair
Adipose Tissue
Skeletal Muscle
Breast
Clinical Trials
Bone and Bones
Skin
Brain

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism

Cite this

Tissue-specific effects of loss of estrogen during menopause and aging. / Wend, Korinna; Wend, Peter; Miranda, Susan.

In: Frontiers in Endocrinology, Vol. 3, No. FEB, Article 19, 01.12.2012.

Research output: Contribution to journalReview article

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