TMC-1 attenuates C. Elegans development and sexual behaviour in a chemically defined food environment

Liusuo Zhang, Daisy G. Gualberto, Xiaoyan Guo, Paola Correa, Chang Hoon Jee, L. Rene Garcia

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Although diet affects growth and behaviour, the adaptive mechanisms that coordinate these processes in non-optimal food sources are unclear. Here we show that the C. Elegans tmc-1 channel, which is homologous to the mammalian tmc deafness genes, attenuates development and inhibits sexual behaviour in non-optimal food, the synthetic CeMM medium. In CeMM medium, signalling from the pharyngeal MC neurons and body wall muscles slows larval development. However, in the non-standard diet, mutation in tmc-1 accelerates development, by impairing the excitability of these cells. The tmc-1 larva can immediately generate ATP when fed CeMM, and their fast development requires insulin signalling. Our findings suggest that the tmc-1 channel indirectly affects metabolism in wild-type animals. In addition to regulating the development, we show that mutating tmc-1 can relax diet-induced inhibition of male sexual behaviour, thus indicating that a single regulator can be genetically modified to promote growth rate and reproductive success in new environments.

Original languageEnglish (US)
Article number6345
JournalNature Communications
Volume6
DOIs
StatePublished - Jan 1 2015

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Nutrition
food
Sexual Behavior
diets
Diet
Food
Wild Animals
Psychological Adaptation
Deafness
Growth
Metabolism
Neurons
Larva
Muscle
Animals
larvae
Genes
Adenosine Triphosphate
auditory defects
insulin

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

TMC-1 attenuates C. Elegans development and sexual behaviour in a chemically defined food environment. / Zhang, Liusuo; Gualberto, Daisy G.; Guo, Xiaoyan; Correa, Paola; Jee, Chang Hoon; Garcia, L. Rene.

In: Nature Communications, Vol. 6, 6345, 01.01.2015.

Research output: Contribution to journalArticle

Zhang, Liusuo ; Gualberto, Daisy G. ; Guo, Xiaoyan ; Correa, Paola ; Jee, Chang Hoon ; Garcia, L. Rene. / TMC-1 attenuates C. Elegans development and sexual behaviour in a chemically defined food environment. In: Nature Communications. 2015 ; Vol. 6.
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AU - Jee, Chang Hoon

AU - Garcia, L. Rene

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