Tocainide therapy in muscle cramps and spasms due to neuromuscular disease

Trilok S. Puniani, Tulio Bertorini

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Significant improvement in symptoms of disabling cramps and muscle spasms was obtained in 9 patients with motor neuron diseases, tetany, and myotonic disorders who were treated with tocainide, a lidocaine analog. No significant side effects were observed except for light‐headedness and fatigue in 1 patient, who also showed slight prolongation of intraventricular conduction time. Tocainide is useful in treating disabling muscle spasms and cramps associated with conditions characterized by neuromuscular irritability. This effect is probably based on stabilization of the membrane potential at various levels (motor neurons, peripheral nerve, or muscle fiber membrane).

Original languageEnglish (US)
Pages (from-to)280-285
Number of pages6
JournalMuscle & Nerve
Volume14
Issue number3
DOIs
StatePublished - Jan 1 1991

Fingerprint

Tocainide
Muscle Cramp
Neuromuscular Diseases
Spasm
Myotonic Disorders
Tetany
Motor Neuron Disease
Dizziness
Motor Neurons
Lidocaine
Peripheral Nerves
Membrane Potentials
Fatigue
Muscles
Membranes
Therapeutics

All Science Journal Classification (ASJC) codes

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)

Cite this

Tocainide therapy in muscle cramps and spasms due to neuromuscular disease. / Puniani, Trilok S.; Bertorini, Tulio.

In: Muscle & Nerve, Vol. 14, No. 3, 01.01.1991, p. 280-285.

Research output: Contribution to journalArticle

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