Toll-deficient Drosophila are resistant to infection by Pneumocystis spp. additional evidence of specificity to mammalian hosts

Scott E. Evans, Konstantinos Leventakos, Ronen Ben-Ami, Dahui You, Sachin G. Thakkar, Russell E. Lewis, Dimitrios P. Kontoyiannis

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Pneumocystis spp. are significant pathogens in a variety of mammals. We tried to establish a Drosophila model of pneumocystosis using either P. murina or P. carinii. Whereas the pathogens were competent in susceptible mice, no infection could be established even in corticosteroid-treated Toll-deficient flies. This further substantiates the tropism described for mammalian hosts.

Original languageEnglish (US)
Pages (from-to)523-525
Number of pages3
JournalVirulence
Volume1
Issue number6
DOIs
StatePublished - Jan 1 2010

Fingerprint

Pneumocystis
Pneumocystis Infections
Murinae
Tropism
Pneumocystis Pneumonia
Diptera
Drosophila
Mammals
Adrenal Cortex Hormones
Infection

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Microbiology
  • Immunology
  • Microbiology (medical)
  • Infectious Diseases

Cite this

Evans, S. E., Leventakos, K., Ben-Ami, R., You, D., Thakkar, S. G., Lewis, R. E., & Kontoyiannis, D. P. (2010). Toll-deficient Drosophila are resistant to infection by Pneumocystis spp. additional evidence of specificity to mammalian hosts. Virulence, 1(6), 523-525. https://doi.org/10.4161/viru.1.6.13903

Toll-deficient Drosophila are resistant to infection by Pneumocystis spp. additional evidence of specificity to mammalian hosts. / Evans, Scott E.; Leventakos, Konstantinos; Ben-Ami, Ronen; You, Dahui; Thakkar, Sachin G.; Lewis, Russell E.; Kontoyiannis, Dimitrios P.

In: Virulence, Vol. 1, No. 6, 01.01.2010, p. 523-525.

Research output: Contribution to journalArticle

Evans, SE, Leventakos, K, Ben-Ami, R, You, D, Thakkar, SG, Lewis, RE & Kontoyiannis, DP 2010, 'Toll-deficient Drosophila are resistant to infection by Pneumocystis spp. additional evidence of specificity to mammalian hosts', Virulence, vol. 1, no. 6, pp. 523-525. https://doi.org/10.4161/viru.1.6.13903
Evans, Scott E. ; Leventakos, Konstantinos ; Ben-Ami, Ronen ; You, Dahui ; Thakkar, Sachin G. ; Lewis, Russell E. ; Kontoyiannis, Dimitrios P. / Toll-deficient Drosophila are resistant to infection by Pneumocystis spp. additional evidence of specificity to mammalian hosts. In: Virulence. 2010 ; Vol. 1, No. 6. pp. 523-525.
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