Toll-like receptors in antiviral innate immunity

Sandra N. Lester, Kui Li

Research output: Contribution to journalReview article

153 Citations (Scopus)

Abstract

Toll-like receptors (TLRs) are fundamental sensor molecules of the host innate immune system, which detect conserved molecular signatures of a wide range of microbial pathogens and initiate innate immune responses via distinct signaling pathways. Various TLRs are implicated in the early interplay of host cells with invading viruses, which regulates viral replication and/or host responses, ultimately impacting on viral pathogenesis. To survive the host innate defense mechanisms, many viruses have developed strategies to evade or counteract signaling through the TLR pathways, creating an advantageous environment for their propagation. Here we review the current knowledge of the roles TLRs play in antiviral innate immune responses, discuss examples of TLR-mediated viral recognition, and describe strategies used by viruses to antagonize the host antiviral innate immune responses.

Original languageEnglish (US)
Pages (from-to)1246-1264
Number of pages19
JournalJournal of Molecular Biology
Volume426
Issue number6
DOIs
StatePublished - Mar 20 2014

Fingerprint

Toll-Like Receptors
Innate Immunity
Antiviral Agents
Viruses
Immune System

All Science Journal Classification (ASJC) codes

  • Molecular Biology

Cite this

Toll-like receptors in antiviral innate immunity. / Lester, Sandra N.; Li, Kui.

In: Journal of Molecular Biology, Vol. 426, No. 6, 20.03.2014, p. 1246-1264.

Research output: Contribution to journalReview article

Lester, Sandra N. ; Li, Kui. / Toll-like receptors in antiviral innate immunity. In: Journal of Molecular Biology. 2014 ; Vol. 426, No. 6. pp. 1246-1264.
@article{497405c182f048b892982c7d1c9e36a8,
title = "Toll-like receptors in antiviral innate immunity",
abstract = "Toll-like receptors (TLRs) are fundamental sensor molecules of the host innate immune system, which detect conserved molecular signatures of a wide range of microbial pathogens and initiate innate immune responses via distinct signaling pathways. Various TLRs are implicated in the early interplay of host cells with invading viruses, which regulates viral replication and/or host responses, ultimately impacting on viral pathogenesis. To survive the host innate defense mechanisms, many viruses have developed strategies to evade or counteract signaling through the TLR pathways, creating an advantageous environment for their propagation. Here we review the current knowledge of the roles TLRs play in antiviral innate immune responses, discuss examples of TLR-mediated viral recognition, and describe strategies used by viruses to antagonize the host antiviral innate immune responses.",
author = "Lester, {Sandra N.} and Kui Li",
year = "2014",
month = "3",
day = "20",
doi = "10.1016/j.jmb.2013.11.024",
language = "English (US)",
volume = "426",
pages = "1246--1264",
journal = "Journal of Molecular Biology",
issn = "0022-2836",
publisher = "Academic Press Inc.",
number = "6",

}

TY - JOUR

T1 - Toll-like receptors in antiviral innate immunity

AU - Lester, Sandra N.

AU - Li, Kui

PY - 2014/3/20

Y1 - 2014/3/20

N2 - Toll-like receptors (TLRs) are fundamental sensor molecules of the host innate immune system, which detect conserved molecular signatures of a wide range of microbial pathogens and initiate innate immune responses via distinct signaling pathways. Various TLRs are implicated in the early interplay of host cells with invading viruses, which regulates viral replication and/or host responses, ultimately impacting on viral pathogenesis. To survive the host innate defense mechanisms, many viruses have developed strategies to evade or counteract signaling through the TLR pathways, creating an advantageous environment for their propagation. Here we review the current knowledge of the roles TLRs play in antiviral innate immune responses, discuss examples of TLR-mediated viral recognition, and describe strategies used by viruses to antagonize the host antiviral innate immune responses.

AB - Toll-like receptors (TLRs) are fundamental sensor molecules of the host innate immune system, which detect conserved molecular signatures of a wide range of microbial pathogens and initiate innate immune responses via distinct signaling pathways. Various TLRs are implicated in the early interplay of host cells with invading viruses, which regulates viral replication and/or host responses, ultimately impacting on viral pathogenesis. To survive the host innate defense mechanisms, many viruses have developed strategies to evade or counteract signaling through the TLR pathways, creating an advantageous environment for their propagation. Here we review the current knowledge of the roles TLRs play in antiviral innate immune responses, discuss examples of TLR-mediated viral recognition, and describe strategies used by viruses to antagonize the host antiviral innate immune responses.

UR - http://www.scopus.com/inward/record.url?scp=84894585119&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84894585119&partnerID=8YFLogxK

U2 - 10.1016/j.jmb.2013.11.024

DO - 10.1016/j.jmb.2013.11.024

M3 - Review article

VL - 426

SP - 1246

EP - 1264

JO - Journal of Molecular Biology

JF - Journal of Molecular Biology

SN - 0022-2836

IS - 6

ER -