Toluidine blue staining in the detection of oral precancerous and malignant lesions

S. Silverman, C. Migliorati, J. Barbosa

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

One hundred thirty-two consecutive patients suspected of having malignant or precancerous oral lesions were studied by comparing toluidine blue dye uptake clinically with a simultaneous biopsy. The histopathologic diagnosis confirmed 57 squamous carcinomas, 42 epithelial dysplasias, and 33 benign mucosal changes. Overall accuracy of the toluidine blue uptake was 91%. In the dysplastic and malignant lesions the false negatives were 2%, and there were 30% false positives in the benign lesions. It was concluded that toluidine blue staining is a useful adjunct to careful examination, clinical judgment, and biopsy.

Original languageEnglish (US)
Pages (from-to)379-382
Number of pages4
JournalOral Surgery, Oral Medicine, Oral Pathology
Volume57
Issue number4
DOIs
StatePublished - Jan 1 1984

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Tolonium Chloride
Staining and Labeling
Biopsy
Squamous Cell Carcinoma
Coloring Agents

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Dentistry(all)

Cite this

Toluidine blue staining in the detection of oral precancerous and malignant lesions. / Silverman, S.; Migliorati, C.; Barbosa, J.

In: Oral Surgery, Oral Medicine, Oral Pathology, Vol. 57, No. 4, 01.01.1984, p. 379-382.

Research output: Contribution to journalArticle

Silverman, S. ; Migliorati, C. ; Barbosa, J. / Toluidine blue staining in the detection of oral precancerous and malignant lesions. In: Oral Surgery, Oral Medicine, Oral Pathology. 1984 ; Vol. 57, No. 4. pp. 379-382.
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