Topical application of β-radiation to reduce intimal hyperplasia after carotid artery balloon injury in rabbit

A possible application for brachytherapy in vascular surgery

David Rosenthal, Scott Stevens, C. S. Skillern, Eric D. Wellons, Keith Robinson, John H. Matsuura, Brian J. Gannon

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Purpose: Endovascular brachytherapy for the prevention of intimal hyperplasia (IH) and restenosis after balloon/stent angioplasty has proven effective both in animal preparations and clinical trials. A variety of β-emitting isotopes and catheter-based devices have been developed for the delivery of low-dose radiation in clinical coronary and peripheral trials. No platform, however, has yet been developed for brachytherapy in concert with vascular surgical operations. The purpose of this study was to evaluate the vascular histopathologic response following balloon injury to rabbit carotid arteries with and without topically applied low-dose β-radiation. Methods: The β-emitting isotope strontium-90 (Sr-90) was conjugated onto the matrix of polypropylene (PLYP) mesh. Rabbit carotid arteries were balloon-injured with a #2 embolectomy catheter. Six carotid arteries were wrapped with nonradioactive PLYP mesh (controls) and Sr-90 (∼90 μCi) PLYP mesh in order to deliver low-dose radiation to the vessel wall from the external (adventitial) surface. Tissue was harvested at 6 weeks and processed for histologic examination. Results: There was consistent blockade of fibrocellular neointima formation with virtually no neointima present in all treated segments, compared to moderate neointima formation in controls. Medial thinning and smooth muscle cell (SMC) necrosis were also associated with topical brachytherapy. Conclusion: β-Radiation applied by an externally wrapped PLYP mesh labeled with Sr-90 markedly suppressed neointima formation in an animal vascular surgical injury model. Further studies, however, are necessary to determine a suitable isotope and dosage for clinical application.

Original languageEnglish (US)
Pages (from-to)16-19
Number of pages4
JournalCardiovascular Radiation Medicine
Volume3
Issue number1
DOIs
StatePublished - Jan 1 2002

Fingerprint

Carotid Artery Injuries
Tunica Intima
Neointima
Polypropylenes
Brachytherapy
Hyperplasia
Blood Vessels
Carotid Arteries
Radiation
Rabbits
Strontium
Isotopes
Strontium Isotopes
Catheters
Embolectomy
Anatomic Models
Adventitia
Balloon Angioplasty
Vascular System Injuries
Intraoperative Complications

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Cardiology and Cardiovascular Medicine
  • Surgery

Cite this

Topical application of β-radiation to reduce intimal hyperplasia after carotid artery balloon injury in rabbit : A possible application for brachytherapy in vascular surgery. / Rosenthal, David; Stevens, Scott; Skillern, C. S.; Wellons, Eric D.; Robinson, Keith; Matsuura, John H.; Gannon, Brian J.

In: Cardiovascular Radiation Medicine, Vol. 3, No. 1, 01.01.2002, p. 16-19.

Research output: Contribution to journalArticle

Rosenthal, David ; Stevens, Scott ; Skillern, C. S. ; Wellons, Eric D. ; Robinson, Keith ; Matsuura, John H. ; Gannon, Brian J. / Topical application of β-radiation to reduce intimal hyperplasia after carotid artery balloon injury in rabbit : A possible application for brachytherapy in vascular surgery. In: Cardiovascular Radiation Medicine. 2002 ; Vol. 3, No. 1. pp. 16-19.
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