Topiramate and metabolic acidosis

Andrew Wilner, Kent Raymond, Richard Pollard

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

Topiramate (TPM) is a novel antiepileptic medication (AED) with at least three mechanisms of action. A possible fourth mechanism, that of a carbonic anhydrase inhibitor, also may contribute to its antiepileptic properties. We report a patient with intractable epilepsy and normal renal function who developed a normal anion gap metabolic acidosis, which worsened during elective surgery for temporal lobectomy. We believe this side effect of TPM can become clinically significant during surgery, concomitant use of another carbonic anhydrase inhibitor, and potentially with the ketogenic diet.

Original languageEnglish (US)
Pages (from-to)792-795
Number of pages4
JournalEpilepsia
Volume40
Issue number6
DOIs
StatePublished - Jan 1 1999

Fingerprint

Carbonic Anhydrase Inhibitors
Acidosis
Anticonvulsants
Ketogenic Diet
Acid-Base Equilibrium
Kidney
topiramate
Drug Resistant Epilepsy

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Topiramate and metabolic acidosis. / Wilner, Andrew; Raymond, Kent; Pollard, Richard.

In: Epilepsia, Vol. 40, No. 6, 01.01.1999, p. 792-795.

Research output: Contribution to journalArticle

Wilner, Andrew ; Raymond, Kent ; Pollard, Richard. / Topiramate and metabolic acidosis. In: Epilepsia. 1999 ; Vol. 40, No. 6. pp. 792-795.
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