Total and individual coronary artery calcium scores as independent predictors of mortality in hemodialysis patients

Ronney S. Shantouf, Matthew J. Budoff, Naser Ahmadi, Arshia Ghaffari, Ferdinand Flores, Ambarish Gopal, Nazanin Noori, Jennie Jing, Csaba Kovesdy, Kamyar Kalantar-Zadeh

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

Many traditional and nontraditional risk factors contribute to vascular calcification among maintenance hemodialysis (MHD) patients. It is not clear whether coronary artery calcification (CAC) delineates a higher mortality risk independent of known risk factors. We examined 6-year (10/2001-9/2007) survival of 166 MHD patients, aged 53 ± 13 years, with baseline CAC scores. Patients were grouped into four CAC groups: 0, 1-100, 101-400, and 400+. The 101-400 and 400+ groups were associated with a significantly higher adjusted risk of death than CAC 0 with hazard ratios (HR) 8.5 (95% CI: 1.1-48.1, p = 0.02) and 13.3 (95% CI: 1.3-65.1, p = 0.01), respectively, independent of demographics, comorbidity, lipids and other cardiovascular risks, surrogates of bone disease, nutritional and inflammatory markers and dialysis dose. Total CAC [HR 6.7 (1.1-21.5, p = 0.03)] followed by the presence of CAC in the left main [4.6 (2.2-9.8, p = 0.001)] and left anterior descending artery [4.3 (2.1-14.2, p = 0.001)] were strong independent predictors of mortality even after adjusting for above covariates. Total and vessel-specific CAC predict mortality in MHD patients independent of traditional and nontraditional risk factors.

Original languageEnglish (US)
Pages (from-to)419-425
Number of pages7
JournalAmerican Journal of Nephrology
Volume31
Issue number5
DOIs
StatePublished - May 1 2010
Externally publishedYes

Fingerprint

Renal Dialysis
Coronary Vessels
Calcium
Mortality
Vascular Calcification
Bone Diseases
Comorbidity
Dialysis
Arteries
Maintenance
Demography
Lipids
Survival

All Science Journal Classification (ASJC) codes

  • Nephrology

Cite this

Shantouf, R. S., Budoff, M. J., Ahmadi, N., Ghaffari, A., Flores, F., Gopal, A., ... Kalantar-Zadeh, K. (2010). Total and individual coronary artery calcium scores as independent predictors of mortality in hemodialysis patients. American Journal of Nephrology, 31(5), 419-425. https://doi.org/10.1159/000294405

Total and individual coronary artery calcium scores as independent predictors of mortality in hemodialysis patients. / Shantouf, Ronney S.; Budoff, Matthew J.; Ahmadi, Naser; Ghaffari, Arshia; Flores, Ferdinand; Gopal, Ambarish; Noori, Nazanin; Jing, Jennie; Kovesdy, Csaba; Kalantar-Zadeh, Kamyar.

In: American Journal of Nephrology, Vol. 31, No. 5, 01.05.2010, p. 419-425.

Research output: Contribution to journalArticle

Shantouf, RS, Budoff, MJ, Ahmadi, N, Ghaffari, A, Flores, F, Gopal, A, Noori, N, Jing, J, Kovesdy, C & Kalantar-Zadeh, K 2010, 'Total and individual coronary artery calcium scores as independent predictors of mortality in hemodialysis patients', American Journal of Nephrology, vol. 31, no. 5, pp. 419-425. https://doi.org/10.1159/000294405
Shantouf, Ronney S. ; Budoff, Matthew J. ; Ahmadi, Naser ; Ghaffari, Arshia ; Flores, Ferdinand ; Gopal, Ambarish ; Noori, Nazanin ; Jing, Jennie ; Kovesdy, Csaba ; Kalantar-Zadeh, Kamyar. / Total and individual coronary artery calcium scores as independent predictors of mortality in hemodialysis patients. In: American Journal of Nephrology. 2010 ; Vol. 31, No. 5. pp. 419-425.
@article{b30ea94ff42141fda0e010f2020e5284,
title = "Total and individual coronary artery calcium scores as independent predictors of mortality in hemodialysis patients",
abstract = "Many traditional and nontraditional risk factors contribute to vascular calcification among maintenance hemodialysis (MHD) patients. It is not clear whether coronary artery calcification (CAC) delineates a higher mortality risk independent of known risk factors. We examined 6-year (10/2001-9/2007) survival of 166 MHD patients, aged 53 ± 13 years, with baseline CAC scores. Patients were grouped into four CAC groups: 0, 1-100, 101-400, and 400+. The 101-400 and 400+ groups were associated with a significantly higher adjusted risk of death than CAC 0 with hazard ratios (HR) 8.5 (95{\%} CI: 1.1-48.1, p = 0.02) and 13.3 (95{\%} CI: 1.3-65.1, p = 0.01), respectively, independent of demographics, comorbidity, lipids and other cardiovascular risks, surrogates of bone disease, nutritional and inflammatory markers and dialysis dose. Total CAC [HR 6.7 (1.1-21.5, p = 0.03)] followed by the presence of CAC in the left main [4.6 (2.2-9.8, p = 0.001)] and left anterior descending artery [4.3 (2.1-14.2, p = 0.001)] were strong independent predictors of mortality even after adjusting for above covariates. Total and vessel-specific CAC predict mortality in MHD patients independent of traditional and nontraditional risk factors.",
author = "Shantouf, {Ronney S.} and Budoff, {Matthew J.} and Naser Ahmadi and Arshia Ghaffari and Ferdinand Flores and Ambarish Gopal and Nazanin Noori and Jennie Jing and Csaba Kovesdy and Kamyar Kalantar-Zadeh",
year = "2010",
month = "5",
day = "1",
doi = "10.1159/000294405",
language = "English (US)",
volume = "31",
pages = "419--425",
journal = "American Journal of Nephrology",
issn = "0250-8095",
publisher = "S. Karger AG",
number = "5",

}

TY - JOUR

T1 - Total and individual coronary artery calcium scores as independent predictors of mortality in hemodialysis patients

AU - Shantouf, Ronney S.

AU - Budoff, Matthew J.

AU - Ahmadi, Naser

AU - Ghaffari, Arshia

AU - Flores, Ferdinand

AU - Gopal, Ambarish

AU - Noori, Nazanin

AU - Jing, Jennie

AU - Kovesdy, Csaba

AU - Kalantar-Zadeh, Kamyar

PY - 2010/5/1

Y1 - 2010/5/1

N2 - Many traditional and nontraditional risk factors contribute to vascular calcification among maintenance hemodialysis (MHD) patients. It is not clear whether coronary artery calcification (CAC) delineates a higher mortality risk independent of known risk factors. We examined 6-year (10/2001-9/2007) survival of 166 MHD patients, aged 53 ± 13 years, with baseline CAC scores. Patients were grouped into four CAC groups: 0, 1-100, 101-400, and 400+. The 101-400 and 400+ groups were associated with a significantly higher adjusted risk of death than CAC 0 with hazard ratios (HR) 8.5 (95% CI: 1.1-48.1, p = 0.02) and 13.3 (95% CI: 1.3-65.1, p = 0.01), respectively, independent of demographics, comorbidity, lipids and other cardiovascular risks, surrogates of bone disease, nutritional and inflammatory markers and dialysis dose. Total CAC [HR 6.7 (1.1-21.5, p = 0.03)] followed by the presence of CAC in the left main [4.6 (2.2-9.8, p = 0.001)] and left anterior descending artery [4.3 (2.1-14.2, p = 0.001)] were strong independent predictors of mortality even after adjusting for above covariates. Total and vessel-specific CAC predict mortality in MHD patients independent of traditional and nontraditional risk factors.

AB - Many traditional and nontraditional risk factors contribute to vascular calcification among maintenance hemodialysis (MHD) patients. It is not clear whether coronary artery calcification (CAC) delineates a higher mortality risk independent of known risk factors. We examined 6-year (10/2001-9/2007) survival of 166 MHD patients, aged 53 ± 13 years, with baseline CAC scores. Patients were grouped into four CAC groups: 0, 1-100, 101-400, and 400+. The 101-400 and 400+ groups were associated with a significantly higher adjusted risk of death than CAC 0 with hazard ratios (HR) 8.5 (95% CI: 1.1-48.1, p = 0.02) and 13.3 (95% CI: 1.3-65.1, p = 0.01), respectively, independent of demographics, comorbidity, lipids and other cardiovascular risks, surrogates of bone disease, nutritional and inflammatory markers and dialysis dose. Total CAC [HR 6.7 (1.1-21.5, p = 0.03)] followed by the presence of CAC in the left main [4.6 (2.2-9.8, p = 0.001)] and left anterior descending artery [4.3 (2.1-14.2, p = 0.001)] were strong independent predictors of mortality even after adjusting for above covariates. Total and vessel-specific CAC predict mortality in MHD patients independent of traditional and nontraditional risk factors.

UR - http://www.scopus.com/inward/record.url?scp=77950598826&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77950598826&partnerID=8YFLogxK

U2 - 10.1159/000294405

DO - 10.1159/000294405

M3 - Article

VL - 31

SP - 419

EP - 425

JO - American Journal of Nephrology

JF - American Journal of Nephrology

SN - 0250-8095

IS - 5

ER -