Trait-specific tracking and determinants of body composition

A 7-year follow-up study of pubertal growth in girls

Sulin Cheng, Eszter Völgyi, Frances Tylavsky, Arja Lyytikäinen, Timo Törmäkangas, Leiting Xu, Shu Mei Cheng, Heikki Kröger, Markku Alèn, Urho M. Kujala

Research output: Contribution to journalArticle

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Abstract

Background: Understanding how bone (BM), lean (LM) and fat mass (FM) develop through childhood, puberty and adolescence is vital since it holds key information regarding current and future health. Our study aimed to determine how BM, LM and FM track from prepuberty to early adulthood in girls and what factors are associated with intra- and inter-individual variation in these three tissues. Methods: The study was a 7-year longitudinal cohort study. BM, LM and FM measured using dual-energy X-ray absorptiometry, self-reported dietary information, leisure time physical activity (LTPA) and other factors were assessed one to eight times in 396 girls aged 10 to 13 years (baseline), and in 255 mothers once. Results: The location of a girl's BM, LM and FM in the lower, middle or upper part of the sample distribution was established before puberty and tracked in its percentile of origin over 7 years (r = 0.72 for BM, r = 0.61 for LM, and r = 0.65 for FM all p < 0.001 first vs. last measurements' ranking). Seventy-three percent of those in the lowest quartile for BM and 69% for LM, and 79% of those in the highest quartile for FM at baseline remained in their quartile at 7-year follow-up. Heritability was estimated to contribute 69% of the total variance of the BM, 50% of the LM, and 57% of the FM. Besides body size, diet index (explaining 9% of variance), breast feeding duration (6%) and mother's BM (9%) predicted high BM. Diet index and high LTPA predicted high LM (24% and 14%, respectively), and low FM (25% and 12%, respectively), and low level of parental education predicted high FM (4%). Conclusion: Individual levels of BM, LM and FM are established before puberty and track in a trait-specific manner until early adulthood. Girls who are prone to develop low BM and LM and high FM in adulthood can be identified in prepuberty. The developments of three components of body composition are inter-related during growth. BM was the most heritable trait while LM the most environmentally modifiable. Diet and physical activity played an important role in increasing LM and preventing the accumulation of excessive FM.

Original languageEnglish (US)
Article number5
JournalBMC Medicine
Volume7
DOIs
StatePublished - Jan 26 2009

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Body Composition
Fats
Growth
Puberty
Leisure Activities
Exercise
Diet
Mothers
Photon Absorptiometry
Body Size
Breast Feeding
Longitudinal Studies
Cohort Studies
Education
Bone and Bones

All Science Journal Classification (ASJC) codes

  • Medicine(all)

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Trait-specific tracking and determinants of body composition : A 7-year follow-up study of pubertal growth in girls. / Cheng, Sulin; Völgyi, Eszter; Tylavsky, Frances; Lyytikäinen, Arja; Törmäkangas, Timo; Xu, Leiting; Cheng, Shu Mei; Kröger, Heikki; Alèn, Markku; Kujala, Urho M.

In: BMC Medicine, Vol. 7, 5, 26.01.2009.

Research output: Contribution to journalArticle

Cheng, S, Völgyi, E, Tylavsky, F, Lyytikäinen, A, Törmäkangas, T, Xu, L, Cheng, SM, Kröger, H, Alèn, M & Kujala, UM 2009, 'Trait-specific tracking and determinants of body composition: A 7-year follow-up study of pubertal growth in girls', BMC Medicine, vol. 7, 5. https://doi.org/10.1186/1741-7015-7-5
Cheng, Sulin ; Völgyi, Eszter ; Tylavsky, Frances ; Lyytikäinen, Arja ; Törmäkangas, Timo ; Xu, Leiting ; Cheng, Shu Mei ; Kröger, Heikki ; Alèn, Markku ; Kujala, Urho M. / Trait-specific tracking and determinants of body composition : A 7-year follow-up study of pubertal growth in girls. In: BMC Medicine. 2009 ; Vol. 7.
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abstract = "Background: Understanding how bone (BM), lean (LM) and fat mass (FM) develop through childhood, puberty and adolescence is vital since it holds key information regarding current and future health. Our study aimed to determine how BM, LM and FM track from prepuberty to early adulthood in girls and what factors are associated with intra- and inter-individual variation in these three tissues. Methods: The study was a 7-year longitudinal cohort study. BM, LM and FM measured using dual-energy X-ray absorptiometry, self-reported dietary information, leisure time physical activity (LTPA) and other factors were assessed one to eight times in 396 girls aged 10 to 13 years (baseline), and in 255 mothers once. Results: The location of a girl's BM, LM and FM in the lower, middle or upper part of the sample distribution was established before puberty and tracked in its percentile of origin over 7 years (r = 0.72 for BM, r = 0.61 for LM, and r = 0.65 for FM all p < 0.001 first vs. last measurements' ranking). Seventy-three percent of those in the lowest quartile for BM and 69{\%} for LM, and 79{\%} of those in the highest quartile for FM at baseline remained in their quartile at 7-year follow-up. Heritability was estimated to contribute 69{\%} of the total variance of the BM, 50{\%} of the LM, and 57{\%} of the FM. Besides body size, diet index (explaining 9{\%} of variance), breast feeding duration (6{\%}) and mother's BM (9{\%}) predicted high BM. Diet index and high LTPA predicted high LM (24{\%} and 14{\%}, respectively), and low FM (25{\%} and 12{\%}, respectively), and low level of parental education predicted high FM (4{\%}). Conclusion: Individual levels of BM, LM and FM are established before puberty and track in a trait-specific manner until early adulthood. Girls who are prone to develop low BM and LM and high FM in adulthood can be identified in prepuberty. The developments of three components of body composition are inter-related during growth. BM was the most heritable trait while LM the most environmentally modifiable. Diet and physical activity played an important role in increasing LM and preventing the accumulation of excessive FM.",
author = "Sulin Cheng and Eszter V{\"o}lgyi and Frances Tylavsky and Arja Lyytik{\"a}inen and Timo T{\"o}rm{\"a}kangas and Leiting Xu and Cheng, {Shu Mei} and Heikki Kr{\"o}ger and Markku Al{\`e}n and Kujala, {Urho M.}",
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T1 - Trait-specific tracking and determinants of body composition

T2 - A 7-year follow-up study of pubertal growth in girls

AU - Cheng, Sulin

AU - Völgyi, Eszter

AU - Tylavsky, Frances

AU - Lyytikäinen, Arja

AU - Törmäkangas, Timo

AU - Xu, Leiting

AU - Cheng, Shu Mei

AU - Kröger, Heikki

AU - Alèn, Markku

AU - Kujala, Urho M.

PY - 2009/1/26

Y1 - 2009/1/26

N2 - Background: Understanding how bone (BM), lean (LM) and fat mass (FM) develop through childhood, puberty and adolescence is vital since it holds key information regarding current and future health. Our study aimed to determine how BM, LM and FM track from prepuberty to early adulthood in girls and what factors are associated with intra- and inter-individual variation in these three tissues. Methods: The study was a 7-year longitudinal cohort study. BM, LM and FM measured using dual-energy X-ray absorptiometry, self-reported dietary information, leisure time physical activity (LTPA) and other factors were assessed one to eight times in 396 girls aged 10 to 13 years (baseline), and in 255 mothers once. Results: The location of a girl's BM, LM and FM in the lower, middle or upper part of the sample distribution was established before puberty and tracked in its percentile of origin over 7 years (r = 0.72 for BM, r = 0.61 for LM, and r = 0.65 for FM all p < 0.001 first vs. last measurements' ranking). Seventy-three percent of those in the lowest quartile for BM and 69% for LM, and 79% of those in the highest quartile for FM at baseline remained in their quartile at 7-year follow-up. Heritability was estimated to contribute 69% of the total variance of the BM, 50% of the LM, and 57% of the FM. Besides body size, diet index (explaining 9% of variance), breast feeding duration (6%) and mother's BM (9%) predicted high BM. Diet index and high LTPA predicted high LM (24% and 14%, respectively), and low FM (25% and 12%, respectively), and low level of parental education predicted high FM (4%). Conclusion: Individual levels of BM, LM and FM are established before puberty and track in a trait-specific manner until early adulthood. Girls who are prone to develop low BM and LM and high FM in adulthood can be identified in prepuberty. The developments of three components of body composition are inter-related during growth. BM was the most heritable trait while LM the most environmentally modifiable. Diet and physical activity played an important role in increasing LM and preventing the accumulation of excessive FM.

AB - Background: Understanding how bone (BM), lean (LM) and fat mass (FM) develop through childhood, puberty and adolescence is vital since it holds key information regarding current and future health. Our study aimed to determine how BM, LM and FM track from prepuberty to early adulthood in girls and what factors are associated with intra- and inter-individual variation in these three tissues. Methods: The study was a 7-year longitudinal cohort study. BM, LM and FM measured using dual-energy X-ray absorptiometry, self-reported dietary information, leisure time physical activity (LTPA) and other factors were assessed one to eight times in 396 girls aged 10 to 13 years (baseline), and in 255 mothers once. Results: The location of a girl's BM, LM and FM in the lower, middle or upper part of the sample distribution was established before puberty and tracked in its percentile of origin over 7 years (r = 0.72 for BM, r = 0.61 for LM, and r = 0.65 for FM all p < 0.001 first vs. last measurements' ranking). Seventy-three percent of those in the lowest quartile for BM and 69% for LM, and 79% of those in the highest quartile for FM at baseline remained in their quartile at 7-year follow-up. Heritability was estimated to contribute 69% of the total variance of the BM, 50% of the LM, and 57% of the FM. Besides body size, diet index (explaining 9% of variance), breast feeding duration (6%) and mother's BM (9%) predicted high BM. Diet index and high LTPA predicted high LM (24% and 14%, respectively), and low FM (25% and 12%, respectively), and low level of parental education predicted high FM (4%). Conclusion: Individual levels of BM, LM and FM are established before puberty and track in a trait-specific manner until early adulthood. Girls who are prone to develop low BM and LM and high FM in adulthood can be identified in prepuberty. The developments of three components of body composition are inter-related during growth. BM was the most heritable trait while LM the most environmentally modifiable. Diet and physical activity played an important role in increasing LM and preventing the accumulation of excessive FM.

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