Trans-ethnic association study of blood pressure determinants in over 750,000 individuals

Understanding Society Scientific Group, International Consortium for Blood Pressure, Blood Pressure-International Consortium of Exome Chip Studies, Million Veteran Program

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

In this trans-ethnic multi-omic study, we reinterpret the genetic architecture of blood pressure to identify genes, tissues, phenomes and medication contexts of blood pressure homeostasis. We discovered 208 novel common blood pressure SNPs and 53 rare variants in genome-wide association studies of systolic, diastolic and pulse pressure in up to 776,078 participants from the Million Veteran Program (MVP) and collaborating studies, with analysis of the blood pressure clinical phenome in MVP. Our transcriptome-wide association study detected 4,043 blood pressure associations with genetically predicted gene expression of 840 genes in 45 tissues, and mouse renal single-cell RNA sequencing identified upregulated blood pressure genes in kidney tubule cells.

Original languageEnglish (US)
Pages (from-to)51-62
Number of pages12
JournalNature Genetics
Volume51
Issue number1
DOIs
StatePublished - Jan 1 2019

Fingerprint

Blood Pressure
Veterans
Kidney Tubules
Genes
RNA Sequence Analysis
Genome-Wide Association Study
Transcriptome
Single Nucleotide Polymorphism
Homeostasis
Kidney
Gene Expression

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

Understanding Society Scientific Group, International Consortium for Blood Pressure, Blood Pressure-International Consortium of Exome Chip Studies, & Million Veteran Program (2019). Trans-ethnic association study of blood pressure determinants in over 750,000 individuals. Nature Genetics, 51(1), 51-62. https://doi.org/10.1038/s41588-018-0303-9

Trans-ethnic association study of blood pressure determinants in over 750,000 individuals. / Understanding Society Scientific Group; International Consortium for Blood Pressure; Blood Pressure-International Consortium of Exome Chip Studies; Million Veteran Program.

In: Nature Genetics, Vol. 51, No. 1, 01.01.2019, p. 51-62.

Research output: Contribution to journalArticle

Understanding Society Scientific Group, International Consortium for Blood Pressure, Blood Pressure-International Consortium of Exome Chip Studies & Million Veteran Program 2019, 'Trans-ethnic association study of blood pressure determinants in over 750,000 individuals', Nature Genetics, vol. 51, no. 1, pp. 51-62. https://doi.org/10.1038/s41588-018-0303-9
Understanding Society Scientific Group, International Consortium for Blood Pressure, Blood Pressure-International Consortium of Exome Chip Studies, Million Veteran Program. Trans-ethnic association study of blood pressure determinants in over 750,000 individuals. Nature Genetics. 2019 Jan 1;51(1):51-62. https://doi.org/10.1038/s41588-018-0303-9
Understanding Society Scientific Group ; International Consortium for Blood Pressure ; Blood Pressure-International Consortium of Exome Chip Studies ; Million Veteran Program. / Trans-ethnic association study of blood pressure determinants in over 750,000 individuals. In: Nature Genetics. 2019 ; Vol. 51, No. 1. pp. 51-62.
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