Transformation of human kidney proximal tubule cells by ras-containing retroviruses. Implications for tumor progression

D. M. Nanus, S. A.D. Ebrahim, N. H. Bander, F. X. Real, Lawrence Pfeffer, J. R. Shapiro, A. P. Albino

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Normal human kidney proximal tubule cells into which a ras oncogene was inserted undergo a series of transformation-related alterations that are characteristic of renal carcinomas. These incloude changes in morphology, growth potential, anchorage dependence, antigen expression, growth factor production, and chromosomal stability. Further, there are spontaneous progressive alterations in vitro in the karyotype and antigenic profile of the transformed cells. Cytogenetic analyses suggest that alterations of chromosome 21 may play an early and pivotal role in the development of transformed proximal tubule cells.

Original languageEnglish (US)
Pages (from-to)953-972
Number of pages20
JournalJournal of Experimental Medicine
Volume169
Issue number3
DOIs
StatePublished - Jan 1 1989

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Proximal Kidney Tubule
Retroviridae
Chromosomes, Human, Pair 21
Neoplasms
Chromosomal Instability
ras Genes
Cytogenetic Analysis
Karyotype
Intercellular Signaling Peptides and Proteins
Carcinoma
Kidney
Antigens
Growth

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

Transformation of human kidney proximal tubule cells by ras-containing retroviruses. Implications for tumor progression. / Nanus, D. M.; Ebrahim, S. A.D.; Bander, N. H.; Real, F. X.; Pfeffer, Lawrence; Shapiro, J. R.; Albino, A. P.

In: Journal of Experimental Medicine, Vol. 169, No. 3, 01.01.1989, p. 953-972.

Research output: Contribution to journalArticle

Nanus, D. M. ; Ebrahim, S. A.D. ; Bander, N. H. ; Real, F. X. ; Pfeffer, Lawrence ; Shapiro, J. R. ; Albino, A. P. / Transformation of human kidney proximal tubule cells by ras-containing retroviruses. Implications for tumor progression. In: Journal of Experimental Medicine. 1989 ; Vol. 169, No. 3. pp. 953-972.
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