Transforming growth factor β and monocyte chemotactic protein-1 are elevated in cerebrospinal fluid of immunocompromised patients with HIV-1 infection

Mahlon Johnson, P. Kim, W. Tourtellotte, C. F. Federspiel

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Monocyte infiltration of the brain is central to the pathogenesis of HIV-1 encephalitis. The cytokines promoting recruitment of monocytes into the central nervous system during HIV-1 infection are not established. In this study, we evaluated human cerebrospinal fluid from patients with HIV-1 infection for transforming growth factor β1 (TGFβ1) and monocyte chemotactic protein-1 (MCP-1) using a quantitative sandwich enzyme-linked immunoassays. Cytokine levels were compared to those from patients with multiple sclerosis and normal controls. In cerebrospinal fluid of patients with HIV-1 infection and CD4 < 500 cells/mm 3, both TGFβ1 and MCP-1 were significantly elevated compared to those with CD4 > 500 cells/mm 3, multiple sclerosis, and controls.

Original languageEnglish (US)
Pages (from-to)33-43
Number of pages11
JournalJournal of Neuro-AIDS
Volume2
Issue number4
DOIs
StatePublished - Dec 1 2004

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Chemokine CCL2
Immunocompromised Host
Transforming Growth Factors
HIV Infections
Cerebrospinal Fluid
HIV-1
Multiple Sclerosis
Monocytes
Cytokines
Encephalitis
Immunoenzyme Techniques
Central Nervous System
Brain

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

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Transforming growth factor β and monocyte chemotactic protein-1 are elevated in cerebrospinal fluid of immunocompromised patients with HIV-1 infection. / Johnson, Mahlon; Kim, P.; Tourtellotte, W.; Federspiel, C. F.

In: Journal of Neuro-AIDS, Vol. 2, No. 4, 01.12.2004, p. 33-43.

Research output: Contribution to journalArticle

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