Transgenic animal models

Matteo Vatta, Zhao Yang, Jeffrey Towbin

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Abstract

Arrhythmogenic right ventricular cardiomyopathy (ARVC/D) is a paradigm shifting disorder that primarily affects the right ventricular (RV) myocardium early in the course of disease with later-onset left ventricular (LV) disease [1]. Clinically, the disease is classically characterized by ventricular arrhythmias of RV origin, as noted by ventricular tachycardia (VT) with a left bundle branch block (LBBB) morphology, commonly associated with syncope or sudden cardiac death (SCD) [2]. In addition, affected individuals may develop right heart failure and ultimately biventricular failure. In most cases, age of onset occurs in the teenage years or beyond, more often in males than females [3]. In the Veneto region of Italy, the disorder has been described as the most common cause of SCD in young, healthy, and athletic individuals, in contradistinction to that title given to hypertrophic cardiomyopathy (HCM) in the United States (US) [2, 4, 5]. In the US, ARVC/D is believed to be responsible for approximately 5% of unexplained cases of SCD in young athletic individuals while this number rises to 25%-30% in Italy [5].

Original languageEnglish (US)
Title of host publicationArrhythmogenic RV Cardiomyopathy/Dysplasia
Subtitle of host publicationRecent Advances
PublisherSpringer Milan
Pages61-68
Number of pages8
ISBN (Print)9788847004894
DOIs
StatePublished - Dec 1 2007
Externally publishedYes

Fingerprint

Genetically Modified Animals
Sudden Cardiac Death
Arrhythmogenic Right Ventricular Dysplasia
Animal Models
Italy
Sports
Bundle-Branch Block
Hypertrophic Cardiomyopathy
Syncope
Ventricular Tachycardia
Age of Onset
Cardiac Arrhythmias
Myocardium
Heart Failure

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Vatta, M., Yang, Z., & Towbin, J. (2007). Transgenic animal models. In Arrhythmogenic RV Cardiomyopathy/Dysplasia: Recent Advances (pp. 61-68). Springer Milan. https://doi.org/10.1007/978-88-470-0490-0_8

Transgenic animal models. / Vatta, Matteo; Yang, Zhao; Towbin, Jeffrey.

Arrhythmogenic RV Cardiomyopathy/Dysplasia: Recent Advances. Springer Milan, 2007. p. 61-68.

Research output: Chapter in Book/Report/Conference proceedingChapter

Vatta, M, Yang, Z & Towbin, J 2007, Transgenic animal models. in Arrhythmogenic RV Cardiomyopathy/Dysplasia: Recent Advances. Springer Milan, pp. 61-68. https://doi.org/10.1007/978-88-470-0490-0_8
Vatta M, Yang Z, Towbin J. Transgenic animal models. In Arrhythmogenic RV Cardiomyopathy/Dysplasia: Recent Advances. Springer Milan. 2007. p. 61-68 https://doi.org/10.1007/978-88-470-0490-0_8
Vatta, Matteo ; Yang, Zhao ; Towbin, Jeffrey. / Transgenic animal models. Arrhythmogenic RV Cardiomyopathy/Dysplasia: Recent Advances. Springer Milan, 2007. pp. 61-68
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