Transluminal aortic valve placement

A feasibility study with a newly designed collapsible aortic valve

Nader Moazami, Marc Bessler, Michael Argenziano, Asim Choudhri, Santos E. Cabreriza, John D.F. Allendorf, Eric A. Rose, Mehmet C. Oz

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Percutaneous stents are used in vascular applications in conjunction with angioplasty and in combination with graft material for repair of abdominal aneurysms. The authors have designed a collapsible bioprosthetic aortic valve for placement by a transluminal catheter technique. This trileaflet stent valve is composed of stainless steel and bovine pericardium. Stent valves, 23 and 29 mm, were tested in a pulse duplicator system with rigid rings from 21 to 31 mm in 2 mm increments. At a mean flow of 3.1 L/min (±0.7), normal systemic aortic pressure was generated with a transvalvular gradient of 14.9 ± 7 mmHg (mean ± SD). Regurgitation fraction ranged from 10 to 18% (mean 13.8 ± 3%) in the best ring size. Valves with the best hemodynamic profile were used for implantation in three 70 kg pigs in an open chest model. The valve was collapsed in a 24 Fr catheter designed to allow slow, controlled release. After resection of the native leaflets, the new valve was placed in the subcoronary position. No additional sutures were used for securing the valve. Two animals were successfully weaned from cardiopulmonary bypass and maintained systemic pressures of 100/45 (±10) and 116/70 (±15) mmHg, respectively. Intraoperative color echocardiography revealed minimal regurgitation, central flow, full apposition of all leaflets, and no interference with coronary blood flow. Both animals were sacrificed after being off bypass for 2 hr. Postmortem examination revealed the valves to be securely anchored. The third animal was weaned from cardiopulmonary bypass but developed refractory ventricular fibrillation because of valve dislodgment due to structural failure. Although long term survival data are needed, development of a hemodynamically acceptable prosthetic aortic valve for transluminal placement is feasible.

Original languageEnglish (US)
JournalASAIO Journal
Volume42
Issue number5
StatePublished - Sep 1 1996

Fingerprint

Stents
Feasibility Studies
Aortic Valve
Animals
Catheters
Cardiopulmonary Bypass
Echocardiography
Pericardium
Stainless Steel
Hemodynamics
Ventricular Fibrillation
Prosthetics
Angioplasty
Grafts
Refractory materials
Sutures
Aneurysm
Blood Vessels
Autopsy
Arterial Pressure

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

Cite this

Moazami, N., Bessler, M., Argenziano, M., Choudhri, A., Cabreriza, S. E., Allendorf, J. D. F., ... Oz, M. C. (1996). Transluminal aortic valve placement: A feasibility study with a newly designed collapsible aortic valve. ASAIO Journal, 42(5).

Transluminal aortic valve placement : A feasibility study with a newly designed collapsible aortic valve. / Moazami, Nader; Bessler, Marc; Argenziano, Michael; Choudhri, Asim; Cabreriza, Santos E.; Allendorf, John D.F.; Rose, Eric A.; Oz, Mehmet C.

In: ASAIO Journal, Vol. 42, No. 5, 01.09.1996.

Research output: Contribution to journalArticle

Moazami, N, Bessler, M, Argenziano, M, Choudhri, A, Cabreriza, SE, Allendorf, JDF, Rose, EA & Oz, MC 1996, 'Transluminal aortic valve placement: A feasibility study with a newly designed collapsible aortic valve', ASAIO Journal, vol. 42, no. 5.
Moazami N, Bessler M, Argenziano M, Choudhri A, Cabreriza SE, Allendorf JDF et al. Transluminal aortic valve placement: A feasibility study with a newly designed collapsible aortic valve. ASAIO Journal. 1996 Sep 1;42(5).
Moazami, Nader ; Bessler, Marc ; Argenziano, Michael ; Choudhri, Asim ; Cabreriza, Santos E. ; Allendorf, John D.F. ; Rose, Eric A. ; Oz, Mehmet C. / Transluminal aortic valve placement : A feasibility study with a newly designed collapsible aortic valve. In: ASAIO Journal. 1996 ; Vol. 42, No. 5.
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