Transplacental passage of clindamycin from mother to neonate

C. D. Wear, Craig Towers, M. S. Brown, B. Weitz, S. Porter, Lynlee Wolfe

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective: To evaluate maternal and neonatal cord blood levels at delivery in patients receiving 900 mg of clindamycin intravenous (IV) every 8 h. Study design: Prospective study consented every mother that entered labor with a positive group B streptococcal culture, a high-risk penicillin allergy, and sensitivity to clindamycin and erythromycin. Maternal and cord blood clindamycin levels were obtained at delivery. Time from last dose completion to delivery, number of doses administered and body mass index (BMI) were assessed. Results: Twenty-three patients were consented. All maternal clindamycin values were therapeutic and 22 (96%) of the 23 cord blood samples were therapeutic. The mean maternal level was of 4.46 μg ml-1 (range of 0.7 to 8.4 μg ml-1). The mean cord blood level was 3.35 μg ml-1 (range of <0.5 to 6.4 μg ml-1). Conclusion: These data show that the current dosing recommendation of 900 mg of clindamycin IV every 8 h produces therapeutic maternal and cord blood levels.

Original languageEnglish (US)
Pages (from-to)960-961
Number of pages2
JournalJournal of Perinatology
Volume36
Issue number11
DOIs
StatePublished - Nov 1 2016

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Clindamycin
Fetal Blood
Mothers
Newborn Infant
Erythromycin
Penicillins
Hypersensitivity
Body Mass Index
Therapeutics
Prospective Studies

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology

Cite this

Transplacental passage of clindamycin from mother to neonate. / Wear, C. D.; Towers, Craig; Brown, M. S.; Weitz, B.; Porter, S.; Wolfe, Lynlee.

In: Journal of Perinatology, Vol. 36, No. 11, 01.11.2016, p. 960-961.

Research output: Contribution to journalArticle

Wear, C. D. ; Towers, Craig ; Brown, M. S. ; Weitz, B. ; Porter, S. ; Wolfe, Lynlee. / Transplacental passage of clindamycin from mother to neonate. In: Journal of Perinatology. 2016 ; Vol. 36, No. 11. pp. 960-961.
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