Transplanted small bowel and expression of the insulin-like growth factor binding proteins

Mark Corkins, Stuart S. Kaufman, Jon A. Vanderhoof, Yvette Milazzo, Genevieve Holtz, Richard G. MacDonald, Alan Langnas

Research output: Contribution to journalArticle

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Abstract

The insulin-like growth factor binding proteins (IGFBPs) act to modulate the growth and differentiation of the gastrointestinal mucosa by regulating cellular responses to the important mitogens, the insulin-like growth factors (IGFs). The transplanted small bowel must maintain the normal growth factor interrelationships and signaling pathways despite the potential of host rejection. Ostomy effluent of patients after small bowel or combined liver/small bowel transplantation was assayed for IGFBPs to investigate the effect of rejection on the IGF-IGFBP axis. Seventeen patients were studied over an 18-month period. The transplanted small bowel produced no measurable IGFBPs in the ostomy effluent under normal circumstances. However, when rejection was taking place the ostomy effluent was found to have measurable IGFBP levels in 6 of 12 episodes, the 6 episodes occurring in 6 different patients. Mostly, the IGFBPs present did not exhibit a serum-like pattern indicating the secretion of IGFBPs into the effluent was not the result of loss of mucosal barrier integrity. There were no statistically significant differences in protein content of the ostomy fluids in the presence or absence of rejection. Our results suggest that the gastrointestinal IGF axis is altered during some instances of transplanted small bowel rejection, with increased secretion of IGFBPs.

Original languageEnglish (US)
Pages (from-to)206-210
Number of pages5
JournalPediatric Transplantation
Volume2
Issue number3
StatePublished - Aug 1 1998
Externally publishedYes

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Insulin-Like Growth Factor Binding Proteins
Ostomy
Somatomedins
Mitogens
Intercellular Signaling Peptides and Proteins
Mucous Membrane
Transplantation
Liver
Growth

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Transplantation

Cite this

Corkins, M., Kaufman, S. S., Vanderhoof, J. A., Milazzo, Y., Holtz, G., MacDonald, R. G., & Langnas, A. (1998). Transplanted small bowel and expression of the insulin-like growth factor binding proteins. Pediatric Transplantation, 2(3), 206-210.

Transplanted small bowel and expression of the insulin-like growth factor binding proteins. / Corkins, Mark; Kaufman, Stuart S.; Vanderhoof, Jon A.; Milazzo, Yvette; Holtz, Genevieve; MacDonald, Richard G.; Langnas, Alan.

In: Pediatric Transplantation, Vol. 2, No. 3, 01.08.1998, p. 206-210.

Research output: Contribution to journalArticle

Corkins, M, Kaufman, SS, Vanderhoof, JA, Milazzo, Y, Holtz, G, MacDonald, RG & Langnas, A 1998, 'Transplanted small bowel and expression of the insulin-like growth factor binding proteins', Pediatric Transplantation, vol. 2, no. 3, pp. 206-210.
Corkins M, Kaufman SS, Vanderhoof JA, Milazzo Y, Holtz G, MacDonald RG et al. Transplanted small bowel and expression of the insulin-like growth factor binding proteins. Pediatric Transplantation. 1998 Aug 1;2(3):206-210.
Corkins, Mark ; Kaufman, Stuart S. ; Vanderhoof, Jon A. ; Milazzo, Yvette ; Holtz, Genevieve ; MacDonald, Richard G. ; Langnas, Alan. / Transplanted small bowel and expression of the insulin-like growth factor binding proteins. In: Pediatric Transplantation. 1998 ; Vol. 2, No. 3. pp. 206-210.
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