Transurethral photodynamic therapy in benign prostatic hyperplasia

A canine pilot study using benzoporphyrin derivative

Sugandh D. Shetty, James O. Peabody, Elsa R. Beck, Joseph C. Cerny, Mahul Amin, Anna Richter

Research output: Contribution to journalConference article

Abstract

Photodynamic therapy (PDT) principles were evaluated in management of benign prostatic hyperplasia (BPH) in a canine model. Five dogs were injected with benzoporphyrin derivative (BPD) and samples of prostate, bladder, urethra and rectum were taken at 1, 2, 3 and 4 hr. and analyzed for BPD. Next, 16 dogs were treated with 100 Joules at 690 nm light from argon dye laser 1 hr after administration of BPD at 0.5 mg/kg using cylindrical diffuser tip fiber passed transurethrally. The prostates were harvested weekly upto 4 weeks and the size of the lesion was measured and the prostates were examined. Prostate had the highest BPD levels. Hemorrhagic lesion of 2.5 cm in diameter was noted at 1 week after PDT. At 3 and 4 weeks there were changes of glandular atrophy in the periurethral region. Minimally invasive technique of transurethral PDT causes glandular and stromal changes in the periurethral zone and has potential in the treatment of BPH.

Original languageEnglish (US)
Pages (from-to)151-155
Number of pages5
JournalProceedings of SPIE - The International Society for Optical Engineering
Volume3590
StatePublished - Jan 1 1999
Externally publishedYes

Fingerprint

Photodynamic Therapy
Photodynamic therapy
therapy
dogs
Derivatives
Derivative
lesions
atrophy
argon lasers
rectum
bladder
diffusers
Argon lasers
dye lasers
Diffuser
Dye lasers
Dyes
fibers
causes
Fiber

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

Cite this

Transurethral photodynamic therapy in benign prostatic hyperplasia : A canine pilot study using benzoporphyrin derivative. / Shetty, Sugandh D.; Peabody, James O.; Beck, Elsa R.; Cerny, Joseph C.; Amin, Mahul; Richter, Anna.

In: Proceedings of SPIE - The International Society for Optical Engineering, Vol. 3590, 01.01.1999, p. 151-155.

Research output: Contribution to journalConference article

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