Treatment of hyperthyroidism with sodium ipodate (oragrafin) in addition to propylthiouracil and propranolol

Burt Sharp, Allan W. Reed, Ellen I. Tamagna, David L. Geffner, Jerome M. Hershman

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Ten patients with hyperthyroidism due to Graves’ disease were treated with sodium ipodate (1 g daily) in addition to propranolol (P) plus propylthiouracil (PTU; 100 mg every 8 h) and were compared with a control group of 8 patients treated with P and PTU. Patients on P and PTU had a mean (±SEM) basal free T3 index of 387 ± 59 (normal, 70-160) compared with that of 409 ± 47 (P > 0.05) in the sodium ipodate group. The respective basal free T4 index values (normal, 4.5-10.9) were 21.3 ± 2.8 for the controls and 25.9 ± 2.8 for the ipodate group (P > 0.5), and the basal rT3 values were 192 ± 49 and 210 ± 41 (normal, 16-50 ng/dl; P > 0.05). The average percent changes in each thyroid index and in rT3 were calculated. The first 3 days on P and PTU served as the basal period for the control group, and comparisons were made to the following 9 days. The ipodate group received P and PTU for 2.7 ± 0.3 days, and comparisons were made with the interval on ipodate, P, and PTU (mean, 9.1 ± 0.9 days). For the free T3 index, the control group showed a mean decrement of 20.5 ± 4.4% compared with 50.2 ± 3.1% for the ipodate group (P < 0.001). The respective free T4 index decrements were 14.5 ± 4.4% and 18.5 ± 2.7% (P > 0.05). The respective changes in rT3 were -13.4 ± 7.6% and ± 140 ± 26.9% (P < 0.001). In patients with hyperthyroidism, short term daily therapy with sodium ipodate plus P and PTU produces a greater reduction of free T3 index values than that caused by P and PTU alone.

Original languageEnglish (US)
Pages (from-to)622-625
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Volume53
Issue number3
DOIs
StatePublished - Jan 1 1981

Fingerprint

Ipodate
Propylthiouracil
Hyperthyroidism
Propranolol
Control Groups
Therapeutics
Graves Disease
Thyroid Gland
Reference Values
Scanning electron microscopy

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Treatment of hyperthyroidism with sodium ipodate (oragrafin) in addition to propylthiouracil and propranolol. / Sharp, Burt; Reed, Allan W.; Tamagna, Ellen I.; Geffner, David L.; Hershman, Jerome M.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 53, No. 3, 01.01.1981, p. 622-625.

Research output: Contribution to journalArticle

Sharp, Burt ; Reed, Allan W. ; Tamagna, Ellen I. ; Geffner, David L. ; Hershman, Jerome M. / Treatment of hyperthyroidism with sodium ipodate (oragrafin) in addition to propylthiouracil and propranolol. In: Journal of Clinical Endocrinology and Metabolism. 1981 ; Vol. 53, No. 3. pp. 622-625.
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abstract = "Ten patients with hyperthyroidism due to Graves’ disease were treated with sodium ipodate (1 g daily) in addition to propranolol (P) plus propylthiouracil (PTU; 100 mg every 8 h) and were compared with a control group of 8 patients treated with P and PTU. Patients on P and PTU had a mean (±SEM) basal free T3 index of 387 ± 59 (normal, 70-160) compared with that of 409 ± 47 (P > 0.05) in the sodium ipodate group. The respective basal free T4 index values (normal, 4.5-10.9) were 21.3 ± 2.8 for the controls and 25.9 ± 2.8 for the ipodate group (P > 0.5), and the basal rT3 values were 192 ± 49 and 210 ± 41 (normal, 16-50 ng/dl; P > 0.05). The average percent changes in each thyroid index and in rT3 were calculated. The first 3 days on P and PTU served as the basal period for the control group, and comparisons were made to the following 9 days. The ipodate group received P and PTU for 2.7 ± 0.3 days, and comparisons were made with the interval on ipodate, P, and PTU (mean, 9.1 ± 0.9 days). For the free T3 index, the control group showed a mean decrement of 20.5 ± 4.4{\%} compared with 50.2 ± 3.1{\%} for the ipodate group (P < 0.001). The respective free T4 index decrements were 14.5 ± 4.4{\%} and 18.5 ± 2.7{\%} (P > 0.05). The respective changes in rT3 were -13.4 ± 7.6{\%} and ± 140 ± 26.9{\%} (P < 0.001). In patients with hyperthyroidism, short term daily therapy with sodium ipodate plus P and PTU produces a greater reduction of free T3 index values than that caused by P and PTU alone.",
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