Treatment of metastatic retinoblastoma

Carlos Rodriguez-Galindo, Matthew Wilson, Barrett G. Haik, Mindy J. Lipson, Alvida Cain, Thomas E. Merchant, Sue Kaste, Charles B. Pratt

Research output: Contribution to journalArticle

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Abstract

Purpose: The risk for death in patients with retinoblastoma is increased in those who present with metastatic disease, and the role of intensive chemotherapy and autologous hematopoietic stem cell rescue in these patients remains unclear. Design: Nonrandomized interventional case series. Participants: Four consecutive patients with metastatic retinoblastoma. Methods: We treated four patients with retinoblastoma metastatic to the bone and bone marrow with intensive chemotherapy, consolidation with megatherapy, and autologous hematopoietic stem cell rescue. Chemotherapy included courses of carboplatin and etoposide alternating with cyclophosphamide, etoposide, and either carboplatin or cisplatin. Radiation therapy was delivered to areas of bone metastases. Main Outcome Measures: Patient survival. Results: All patients completed and responded to the scheduled therapy; complete response of the bone marrow disease was documented after two courses of chemotherapy in all cases. Two patients are long-term survivors. Conclusions: The treatment described has been successful in obtaining disease-free survival in patients with metastatic retinoblastoma.

Original languageEnglish (US)
Pages (from-to)1237-1240
Number of pages4
JournalOphthalmology
Volume110
Issue number6
DOIs
StatePublished - Jun 1 2003

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Retinoblastoma
Carboplatin
Etoposide
Therapeutics
Hematopoietic Stem Cells
Drug Therapy
Bone Marrow Diseases
Consolidation Chemotherapy
Bone and Bones
Cyclophosphamide
Cisplatin
Disease-Free Survival
Survivors
Radiotherapy
Bone Marrow
Outcome Assessment (Health Care)
Neoplasm Metastasis
Survival

All Science Journal Classification (ASJC) codes

  • Ophthalmology

Cite this

Rodriguez-Galindo, C., Wilson, M., Haik, B. G., Lipson, M. J., Cain, A., Merchant, T. E., ... Pratt, C. B. (2003). Treatment of metastatic retinoblastoma. Ophthalmology, 110(6), 1237-1240. https://doi.org/10.1016/S0161-6420(03)00258-6

Treatment of metastatic retinoblastoma. / Rodriguez-Galindo, Carlos; Wilson, Matthew; Haik, Barrett G.; Lipson, Mindy J.; Cain, Alvida; Merchant, Thomas E.; Kaste, Sue; Pratt, Charles B.

In: Ophthalmology, Vol. 110, No. 6, 01.06.2003, p. 1237-1240.

Research output: Contribution to journalArticle

Rodriguez-Galindo, C, Wilson, M, Haik, BG, Lipson, MJ, Cain, A, Merchant, TE, Kaste, S & Pratt, CB 2003, 'Treatment of metastatic retinoblastoma', Ophthalmology, vol. 110, no. 6, pp. 1237-1240. https://doi.org/10.1016/S0161-6420(03)00258-6
Rodriguez-Galindo C, Wilson M, Haik BG, Lipson MJ, Cain A, Merchant TE et al. Treatment of metastatic retinoblastoma. Ophthalmology. 2003 Jun 1;110(6):1237-1240. https://doi.org/10.1016/S0161-6420(03)00258-6
Rodriguez-Galindo, Carlos ; Wilson, Matthew ; Haik, Barrett G. ; Lipson, Mindy J. ; Cain, Alvida ; Merchant, Thomas E. ; Kaste, Sue ; Pratt, Charles B. / Treatment of metastatic retinoblastoma. In: Ophthalmology. 2003 ; Vol. 110, No. 6. pp. 1237-1240.
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