Treatment of muscle invasive bladder cancer in the elderly

navigating the trade-offs of risk and benefit

Noam Vanderwalde, Michelle T. Chi, Arti Hurria, Matthew D. Galsky, Matthew E. Nielsen

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Purpose: Despite the fact that bladder cancer patients have the highest median age of any type of cancer, older patients with muscle invasion are often under-treated. Methods: In this review, we report the most up to date literature on the patterns of care and treatment of older patients with muscle invasive bladder cancer. Data on under-treatment, geriatric principles, cystectomy, perioperative chemotherapy, and bladder preservation for older patients are presented and analyzed. Conclusion: Chronologic age should not exclude patients from curative-intent therapy. Functional age as determined by geriatric assessments and multidisciplinary evaluation can help clinicians decide on the best course of treatment for individual patients. Cystectomy, perioperative chemotherapy, and curative-intent bladder preservation are reasonable options in healthy older adults. Observation should be limited to patients with extremely poor performance status and very limited life expectancy.

Original languageEnglish (US)
Pages (from-to)3-11
Number of pages9
JournalWorld Journal of Urology
Volume34
Issue number1
DOIs
StatePublished - Jan 1 2016

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Urinary Bladder Neoplasms
Muscles
Cystectomy
Therapeutics
Urinary Bladder
Geriatric Assessment
Drug Therapy
Life Expectancy
Geriatrics
Observation
Neoplasms

All Science Journal Classification (ASJC) codes

  • Urology

Cite this

Treatment of muscle invasive bladder cancer in the elderly : navigating the trade-offs of risk and benefit. / Vanderwalde, Noam; Chi, Michelle T.; Hurria, Arti; Galsky, Matthew D.; Nielsen, Matthew E.

In: World Journal of Urology, Vol. 34, No. 1, 01.01.2016, p. 3-11.

Research output: Contribution to journalArticle

Vanderwalde, Noam ; Chi, Michelle T. ; Hurria, Arti ; Galsky, Matthew D. ; Nielsen, Matthew E. / Treatment of muscle invasive bladder cancer in the elderly : navigating the trade-offs of risk and benefit. In: World Journal of Urology. 2016 ; Vol. 34, No. 1. pp. 3-11.
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