Trichosporon mucoides fungemia in a liver transplant recipient

Case report and review: Case report

Alexandre Lacasse, Kerry Cleveland

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Four months after receiving an orthotopic liver transplant, a 51-year-old man was admitted for progressive liver failure and severe hepatocellular necrosis thought to be due to tacrolimus. During his hospitalization he experienced bloodstream infections including fungemia due to Trichosporon mucoides and prolonged undulating fever despite antifungal and antibacterial treatment. He underwent removal of the allograft and implantation of another liver. Fever continued postoperatively until therapy with posaconazole was initiated. Initiation of posaconazole led to clinical improvement until the patient's demise from bacteremic vancomycin-resistant enterococcal peritonitis. Trichosporonosis appears to be an emerging fungal infection among immunocompromised individuals (including both hematological and solid organ transplant recipients). T. mucoides is a rare cause of systemic infection. When it occurs, trichosporonosis usually is associated with hematological malignancies and, to the best of our knowledge, has not been previously reported in a liver transplant recipient. The optimal treatment is not well defined. We report here the first case using posaconazole for treatment of trichosporonosis in a liver transplant recipient caused by T. mucoides.

Original languageEnglish (US)
Pages (from-to)155-159
Number of pages5
JournalTransplant Infectious Disease
Volume11
Issue number2
DOIs
StatePublished - Apr 1 2009

Fingerprint

Trichosporon
Fungemia
Trichosporonosis
Liver
Fever
Transplants
Mycoses
Liver Failure
Tacrolimus
Hematologic Neoplasms
Vancomycin
Therapeutics
Infection
Peritonitis
Allografts
Hospitalization
Necrosis
Transplant Recipients
posaconazole

All Science Journal Classification (ASJC) codes

  • Infectious Diseases
  • Transplantation

Cite this

Trichosporon mucoides fungemia in a liver transplant recipient : Case report and review: Case report. / Lacasse, Alexandre; Cleveland, Kerry.

In: Transplant Infectious Disease, Vol. 11, No. 2, 01.04.2009, p. 155-159.

Research output: Contribution to journalArticle

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