Trimellitic anhydride-induced airway syndromes: Clinical and immunologic studies

C. Raymond Zeiss, Roy Patterson, Jacob J. Pruzansky, Michael Miller, Michael Rosenberg, Doris Levitz

Research output: Contribution to journalArticle

185 Citations (Scopus)

Abstract

This report describes a spectrum of respiratory symptoms in workers exposed to trimellitic anhydride (TMA), a biologically reactive chemical used in the plastics industry. Fourteen workers who had worked on a unit which synthesized TMA were evaluated by clinical and immunologic methods. Respiratory syndromes induced by TMA inhalation included asthma and rhinitis of the immediate type, late onset asthma with systemic symptoms, and airway irritation. TMA was shown to couple rapidly to human serum albumin, forming an immunoreactive hapten-protein complex. The workers' immunologic reactivity to this complex could be quantitated and correlated with the three respiratory syndromes. The asthma-rhinitis syndrome was mediated by IgE antibody specific for the TMA hapten. The syndrome of late onset asthma with systemic symptoms was accompanied by elevated levels of TMA-specific IgG antibody. Rheumatoid factor in high titer was found in one worker with IgE-mediated asthma and in two workers with asthma of late onset. Lymphocyte reactivity of TMA-HSA was demonstrated in three workers representative of the three clinical syndromes. Leukocyte histamine release was demonstrated to TMA-HSA in one worker with high levels of IgE antibody specific for TMA-HSA who had severe symptoms of acute rhinitis and asthma.

Original languageEnglish (US)
Pages (from-to)96-103
Number of pages8
JournalThe Journal of Allergy and Clinical Immunology
Volume60
Issue number2
DOIs
StatePublished - Jan 1 1977
Externally publishedYes

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Asthma
Rhinitis
Immunoglobulin E
Haptens
Antibodies
Clinical Studies
trimellitic anhydride
Rheumatoid Factor
Histamine Release
Serum Albumin
Inhalation
Plastics
Industry
Leukocytes
Immunoglobulin G
Lymphocytes
Proteins

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

Trimellitic anhydride-induced airway syndromes : Clinical and immunologic studies. / Zeiss, C. Raymond; Patterson, Roy; Pruzansky, Jacob J.; Miller, Michael; Rosenberg, Michael; Levitz, Doris.

In: The Journal of Allergy and Clinical Immunology, Vol. 60, No. 2, 01.01.1977, p. 96-103.

Research output: Contribution to journalArticle

Zeiss, C. Raymond ; Patterson, Roy ; Pruzansky, Jacob J. ; Miller, Michael ; Rosenberg, Michael ; Levitz, Doris. / Trimellitic anhydride-induced airway syndromes : Clinical and immunologic studies. In: The Journal of Allergy and Clinical Immunology. 1977 ; Vol. 60, No. 2. pp. 96-103.
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