Triple-negative breast cancer in African-American women

Disparities versus biology

Eric C. Dietze, Christopher Sistrunk, Gustavo Miranda-Carboni, Ruth O'Regan, Victoria L. Seewaldt

Research output: Contribution to journalReview article

95 Citations (Scopus)

Abstract

Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype that disproportionately affects BRCA1 mutation carriers and young women of African origin. There is evidence that African-American women with TNBC have worse clinical outcomes than women of European descent. However, it is unclear whether survival differences persist after adjusting for disparities in access to health-care treatment, co-morbid disease and income. It remains controversial whether TNBC in African-American women is a molecularly distinct disease or whether African-American women have a higher incidence of aggressive biology driven by disparities: there is evidence in support of both. Understanding the relative contributions of biology and disparities is essential for improving the poor survival rate of African-American women with TNBC.

Original languageEnglish (US)
Pages (from-to)248-254
Number of pages7
JournalNature Reviews Cancer
Volume15
Issue number4
DOIs
StatePublished - Apr 27 2015

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Triple Negative Breast Neoplasms
African Americans
Health Services Accessibility
Survival Rate
Breast Neoplasms
Mutation
Survival
Incidence

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Triple-negative breast cancer in African-American women : Disparities versus biology. / Dietze, Eric C.; Sistrunk, Christopher; Miranda-Carboni, Gustavo; O'Regan, Ruth; Seewaldt, Victoria L.

In: Nature Reviews Cancer, Vol. 15, No. 4, 27.04.2015, p. 248-254.

Research output: Contribution to journalReview article

Dietze, Eric C. ; Sistrunk, Christopher ; Miranda-Carboni, Gustavo ; O'Regan, Ruth ; Seewaldt, Victoria L. / Triple-negative breast cancer in African-American women : Disparities versus biology. In: Nature Reviews Cancer. 2015 ; Vol. 15, No. 4. pp. 248-254.
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