Tubal ligation and ovarian cancer risk in African American women

Chrissy McNamara, Sarah E. Abbott, Elisa V. Bandera, Bo Qin, Lauren C. Peres, Fabian Camacho, Patricia G. Moorman, Anthony J. Alberg, Jill S. Barnholtz-Sloan, Melissa Bondy, Michele L. Cote, Ellen Funkhouser, Edward S. Peters, Ann G. Schwartz, Joellen M. Schildkraut, Paul Terry

Research output: Contribution to journalArticle

Abstract

Purpose: Tubal ligation has been associated with reduced risk of epithelial ovarian cancer (EOC) in studies of primarily white women, but less is known about the association in African American (AA) women. We sought to evaluate the associations among 597 invasive ovarian cancer cases and 742 controls of AA descent recruited from the African American Cancer Epidemiology Study, a population-based case–control study in 11 geographical areas in the US. Methods: Multivariable logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (CI) adjusted for potentially confounding factors. Results: An inverse association between tubal ligation and EOC was observed that was not statistically significant (OR 0.88, 95% CI 0.68–1.14). However, an inverse association with EOC risk was observed among women who had a tubal ligation at age 35 years or older (OR 0.64; 95% CI 0.41–0.98), but not among those who had a tubal ligation before age 35 (OR 0.98; 95% CI 0.74–1.29) (p for interaction = 0.08). The association also varied considerably by tumor subtype. A strong inverse association was observed for endometrioid tumors (OR 0.31, 95% CI 0.14–0.70), whereas associations with mucinous (OR 0.87, 95% CI 0.36–2.12) and serous (OR 0.94, 95% CI 0.71–1.24) tumors were weaker and not statistically significant. A statistically non-significant positive association for clear cell tumors (OR 1.84, 95% CI 0.58–5.82) was based on a low number of cases. Conclusions: Our findings show that tubal ligation may confer a reduced risk for EOC among AA women that is comparable to the associations that have been previously observed in primarily white populations.

Original languageEnglish (US)
Pages (from-to)1033-1041
Number of pages9
JournalCancer Causes and Control
Volume28
Issue number10
DOIs
StatePublished - Oct 1 2017

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Tubal Sterilization
African Americans
Ovarian Neoplasms
Odds Ratio
Confidence Intervals
Neoplasms
Logistic Models
Population
Epidemiology
Ovarian epithelial cancer

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

McNamara, C., Abbott, S. E., Bandera, E. V., Qin, B., Peres, L. C., Camacho, F., ... Terry, P. (2017). Tubal ligation and ovarian cancer risk in African American women. Cancer Causes and Control, 28(10), 1033-1041. https://doi.org/10.1007/s10552-017-0943-6

Tubal ligation and ovarian cancer risk in African American women. / McNamara, Chrissy; Abbott, Sarah E.; Bandera, Elisa V.; Qin, Bo; Peres, Lauren C.; Camacho, Fabian; Moorman, Patricia G.; Alberg, Anthony J.; Barnholtz-Sloan, Jill S.; Bondy, Melissa; Cote, Michele L.; Funkhouser, Ellen; Peters, Edward S.; Schwartz, Ann G.; Schildkraut, Joellen M.; Terry, Paul.

In: Cancer Causes and Control, Vol. 28, No. 10, 01.10.2017, p. 1033-1041.

Research output: Contribution to journalArticle

McNamara, C, Abbott, SE, Bandera, EV, Qin, B, Peres, LC, Camacho, F, Moorman, PG, Alberg, AJ, Barnholtz-Sloan, JS, Bondy, M, Cote, ML, Funkhouser, E, Peters, ES, Schwartz, AG, Schildkraut, JM & Terry, P 2017, 'Tubal ligation and ovarian cancer risk in African American women', Cancer Causes and Control, vol. 28, no. 10, pp. 1033-1041. https://doi.org/10.1007/s10552-017-0943-6
McNamara C, Abbott SE, Bandera EV, Qin B, Peres LC, Camacho F et al. Tubal ligation and ovarian cancer risk in African American women. Cancer Causes and Control. 2017 Oct 1;28(10):1033-1041. https://doi.org/10.1007/s10552-017-0943-6
McNamara, Chrissy ; Abbott, Sarah E. ; Bandera, Elisa V. ; Qin, Bo ; Peres, Lauren C. ; Camacho, Fabian ; Moorman, Patricia G. ; Alberg, Anthony J. ; Barnholtz-Sloan, Jill S. ; Bondy, Melissa ; Cote, Michele L. ; Funkhouser, Ellen ; Peters, Edward S. ; Schwartz, Ann G. ; Schildkraut, Joellen M. ; Terry, Paul. / Tubal ligation and ovarian cancer risk in African American women. In: Cancer Causes and Control. 2017 ; Vol. 28, No. 10. pp. 1033-1041.
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abstract = "Purpose: Tubal ligation has been associated with reduced risk of epithelial ovarian cancer (EOC) in studies of primarily white women, but less is known about the association in African American (AA) women. We sought to evaluate the associations among 597 invasive ovarian cancer cases and 742 controls of AA descent recruited from the African American Cancer Epidemiology Study, a population-based case–control study in 11 geographical areas in the US. Methods: Multivariable logistic regression models were used to estimate odds ratios (OR) and 95{\%} confidence intervals (CI) adjusted for potentially confounding factors. Results: An inverse association between tubal ligation and EOC was observed that was not statistically significant (OR 0.88, 95{\%} CI 0.68–1.14). However, an inverse association with EOC risk was observed among women who had a tubal ligation at age 35 years or older (OR 0.64; 95{\%} CI 0.41–0.98), but not among those who had a tubal ligation before age 35 (OR 0.98; 95{\%} CI 0.74–1.29) (p for interaction = 0.08). The association also varied considerably by tumor subtype. A strong inverse association was observed for endometrioid tumors (OR 0.31, 95{\%} CI 0.14–0.70), whereas associations with mucinous (OR 0.87, 95{\%} CI 0.36–2.12) and serous (OR 0.94, 95{\%} CI 0.71–1.24) tumors were weaker and not statistically significant. A statistically non-significant positive association for clear cell tumors (OR 1.84, 95{\%} CI 0.58–5.82) was based on a low number of cases. Conclusions: Our findings show that tubal ligation may confer a reduced risk for EOC among AA women that is comparable to the associations that have been previously observed in primarily white populations.",
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AU - McNamara, Chrissy

AU - Abbott, Sarah E.

AU - Bandera, Elisa V.

AU - Qin, Bo

AU - Peres, Lauren C.

AU - Camacho, Fabian

AU - Moorman, Patricia G.

AU - Alberg, Anthony J.

AU - Barnholtz-Sloan, Jill S.

AU - Bondy, Melissa

AU - Cote, Michele L.

AU - Funkhouser, Ellen

AU - Peters, Edward S.

AU - Schwartz, Ann G.

AU - Schildkraut, Joellen M.

AU - Terry, Paul

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N2 - Purpose: Tubal ligation has been associated with reduced risk of epithelial ovarian cancer (EOC) in studies of primarily white women, but less is known about the association in African American (AA) women. We sought to evaluate the associations among 597 invasive ovarian cancer cases and 742 controls of AA descent recruited from the African American Cancer Epidemiology Study, a population-based case–control study in 11 geographical areas in the US. Methods: Multivariable logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (CI) adjusted for potentially confounding factors. Results: An inverse association between tubal ligation and EOC was observed that was not statistically significant (OR 0.88, 95% CI 0.68–1.14). However, an inverse association with EOC risk was observed among women who had a tubal ligation at age 35 years or older (OR 0.64; 95% CI 0.41–0.98), but not among those who had a tubal ligation before age 35 (OR 0.98; 95% CI 0.74–1.29) (p for interaction = 0.08). The association also varied considerably by tumor subtype. A strong inverse association was observed for endometrioid tumors (OR 0.31, 95% CI 0.14–0.70), whereas associations with mucinous (OR 0.87, 95% CI 0.36–2.12) and serous (OR 0.94, 95% CI 0.71–1.24) tumors were weaker and not statistically significant. A statistically non-significant positive association for clear cell tumors (OR 1.84, 95% CI 0.58–5.82) was based on a low number of cases. Conclusions: Our findings show that tubal ligation may confer a reduced risk for EOC among AA women that is comparable to the associations that have been previously observed in primarily white populations.

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