Tubular seminoma: An immunohistochemical and DNA flow-cytometric study of four cases

A. Zavala-Pompa, J. Y. Ro, A. K. El-Naggar, Mahul Amin, N. G. Ordonez, A. Sella, A. G. Ayala

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

The histomorphologic features, immunohistochemical reactivity, and DNA content of four cases of a rare tubular variant of seminoma are presented. These neoplasms were characterized by a predominantly tubular architectural pattern that resembled yolk sac tumor, embryonal carcinoma, and sex cord- stromal tumors. The patients' ages were 15, 24, 27, and 44 years. On initial examination, three patients had painless testicular enlargement, and one had a large retroperitoneal mass and a clinically occult primary testicular tumor. The size of the tumors ranged from 1.7 to 6.0 (mean, 4.0) cm. Microscopically, the tumor cells had a tubular or tubulopapillary pattern that consisted of a single layer of cells, often in a back-to-back arrangement with intervening fibrovascular septa. Areas of classic seminoma were present in all cases. Scattered syncytiotrophoblastic giant cells were seen in two tumors. The tumor cells of both the classic and the tubular components of the seminomas were diffusely positive for placental alkaline phosphatase but were negative for cytokeratin and α-fetoprotein. DNA flow- cytometric analysis demonstrated abnormal stemlines with hypotetraploid DNA and a mean DNA index of 1.7 in both the classic and the tubular components. The presence of concurrent areas of classic seminoma, similar cytologic features in the tubular and classic seminoma areas, and the identical immunohistochemical and DNA flow-cytometric findings indicate that tubular seminoma is a histologic variant of seminoma. Although the behavior of the tubular variant appeared not to differ from that of classic seminoma in our small series, its recognition is important in the differential diagnosis and management of testicular masses.

Original languageEnglish (US)
Pages (from-to)397-401
Number of pages5
JournalAmerican Journal of Clinical Pathology
Volume102
Issue number4
DOIs
StatePublished - Jan 1 1994
Externally publishedYes

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Seminoma
DNA
Neoplasms
Sex Cord-Gonadal Stromal Tumors
Fetal Proteins
Embryonal Carcinoma
Endodermal Sinus Tumor
Testicular Neoplasms
Giant Cells
Keratins
Differential Diagnosis

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

Cite this

Zavala-Pompa, A., Ro, J. Y., El-Naggar, A. K., Amin, M., Ordonez, N. G., Sella, A., & Ayala, A. G. (1994). Tubular seminoma: An immunohistochemical and DNA flow-cytometric study of four cases. American Journal of Clinical Pathology, 102(4), 397-401. https://doi.org/10.1093/ajcp/102.4.397

Tubular seminoma : An immunohistochemical and DNA flow-cytometric study of four cases. / Zavala-Pompa, A.; Ro, J. Y.; El-Naggar, A. K.; Amin, Mahul; Ordonez, N. G.; Sella, A.; Ayala, A. G.

In: American Journal of Clinical Pathology, Vol. 102, No. 4, 01.01.1994, p. 397-401.

Research output: Contribution to journalArticle

Zavala-Pompa, A, Ro, JY, El-Naggar, AK, Amin, M, Ordonez, NG, Sella, A & Ayala, AG 1994, 'Tubular seminoma: An immunohistochemical and DNA flow-cytometric study of four cases', American Journal of Clinical Pathology, vol. 102, no. 4, pp. 397-401. https://doi.org/10.1093/ajcp/102.4.397
Zavala-Pompa, A. ; Ro, J. Y. ; El-Naggar, A. K. ; Amin, Mahul ; Ordonez, N. G. ; Sella, A. ; Ayala, A. G. / Tubular seminoma : An immunohistochemical and DNA flow-cytometric study of four cases. In: American Journal of Clinical Pathology. 1994 ; Vol. 102, No. 4. pp. 397-401.
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