TU‐C‐BRB‐07

Comparison of Preclinical and Clinical Conformal Radiation Therapy Techniques and Protocols to Establish a Translational Pathway

S. G. Price, D. Rangaraj, S. Yaddanapudi, Enrique Izaguirre

Research output: Contribution to journalArticle

Abstract

Purpose: The purpose of this study was to compare the techniques and protocols used in clinical radiation therapy and recently developed preclinical image guided micro irradiation to establish a link between small animal conformal irradiation and clinical treatment protocols. This work will establish protocols that, according to treatment site, will facilitate the translation of conclusions from radiobiological experiments to clinical applications, fostering the advancement of radiotherapy. Methods: Data was gathered using our small animal image guided micro irradiation device, the microIGRT, as an example of preclinical techniques which mimic equivalent clinical treatment protocols. The microIGRT utilizes fractionated treatments, multibeam irradiations, modulated beams, image guided treatment verification, and doses to emulate clinical protocols. Consequently, it is well suited to establish parametric comparisons between clinical and preclinical techniques. In this study, we concentrated on two treatment sites, brain and lung, to define treatment conformality index, homogeneity, penumbra, PDD, and fractionated doses to establish a link to guide radiobiological experiments using clinical protocols as a gold standard. Results: Three and five beam irradiations were delivered to a small animal body and head phantom with radiochromic film to simulate lung and brain treatment. A three beam irradiation to the lung yielded a 625 um penumbra. Compare this value with a human treatment penumbra of 1 cm, and penumbra scales as the ratio between body sizes. The homogeneity of our system is similar to the 10% typically used in clinical treatment planning. Conclusions: By comparing preclinical and clinical treatment metrics, the extent of translation can be determined and improved, leading to better understanding of preclinical results and improved correlation with clinical procedures. This will lead to more clinically based preclinical experiments and improve translation efficiency between the two testing environments, thus providing new clinical treatment strategies and improved human cancer treatment.

Original languageEnglish (US)
Pages (from-to)3899-3900
Number of pages2
JournalMedical Physics
Volume39
Issue number6
DOIs
StatePublished - 2012
Externally publishedYes

Fingerprint

Radiotherapy
Clinical Protocols
Therapeutics
Lung
Foster Home Care
Brain
Body Size
Head
Equipment and Supplies

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Radiology Nuclear Medicine and imaging

Cite this

TU‐C‐BRB‐07 : Comparison of Preclinical and Clinical Conformal Radiation Therapy Techniques and Protocols to Establish a Translational Pathway. / Price, S. G.; Rangaraj, D.; Yaddanapudi, S.; Izaguirre, Enrique.

In: Medical Physics, Vol. 39, No. 6, 2012, p. 3899-3900.

Research output: Contribution to journalArticle

@article{fe652e7e764a4ae5ab1984a998e8afb1,
title = "TU‐C‐BRB‐07: Comparison of Preclinical and Clinical Conformal Radiation Therapy Techniques and Protocols to Establish a Translational Pathway",
abstract = "Purpose: The purpose of this study was to compare the techniques and protocols used in clinical radiation therapy and recently developed preclinical image guided micro irradiation to establish a link between small animal conformal irradiation and clinical treatment protocols. This work will establish protocols that, according to treatment site, will facilitate the translation of conclusions from radiobiological experiments to clinical applications, fostering the advancement of radiotherapy. Methods: Data was gathered using our small animal image guided micro irradiation device, the microIGRT, as an example of preclinical techniques which mimic equivalent clinical treatment protocols. The microIGRT utilizes fractionated treatments, multibeam irradiations, modulated beams, image guided treatment verification, and doses to emulate clinical protocols. Consequently, it is well suited to establish parametric comparisons between clinical and preclinical techniques. In this study, we concentrated on two treatment sites, brain and lung, to define treatment conformality index, homogeneity, penumbra, PDD, and fractionated doses to establish a link to guide radiobiological experiments using clinical protocols as a gold standard. Results: Three and five beam irradiations were delivered to a small animal body and head phantom with radiochromic film to simulate lung and brain treatment. A three beam irradiation to the lung yielded a 625 um penumbra. Compare this value with a human treatment penumbra of 1 cm, and penumbra scales as the ratio between body sizes. The homogeneity of our system is similar to the 10{\%} typically used in clinical treatment planning. Conclusions: By comparing preclinical and clinical treatment metrics, the extent of translation can be determined and improved, leading to better understanding of preclinical results and improved correlation with clinical procedures. This will lead to more clinically based preclinical experiments and improve translation efficiency between the two testing environments, thus providing new clinical treatment strategies and improved human cancer treatment.",
author = "Price, {S. G.} and D. Rangaraj and S. Yaddanapudi and Enrique Izaguirre",
year = "2012",
doi = "10.1118/1.4735919",
language = "English (US)",
volume = "39",
pages = "3899--3900",
journal = "Medical Physics",
issn = "0094-2405",
publisher = "AAPM - American Association of Physicists in Medicine",
number = "6",

}

TY - JOUR

T1 - TU‐C‐BRB‐07

T2 - Comparison of Preclinical and Clinical Conformal Radiation Therapy Techniques and Protocols to Establish a Translational Pathway

AU - Price, S. G.

AU - Rangaraj, D.

AU - Yaddanapudi, S.

AU - Izaguirre, Enrique

PY - 2012

Y1 - 2012

N2 - Purpose: The purpose of this study was to compare the techniques and protocols used in clinical radiation therapy and recently developed preclinical image guided micro irradiation to establish a link between small animal conformal irradiation and clinical treatment protocols. This work will establish protocols that, according to treatment site, will facilitate the translation of conclusions from radiobiological experiments to clinical applications, fostering the advancement of radiotherapy. Methods: Data was gathered using our small animal image guided micro irradiation device, the microIGRT, as an example of preclinical techniques which mimic equivalent clinical treatment protocols. The microIGRT utilizes fractionated treatments, multibeam irradiations, modulated beams, image guided treatment verification, and doses to emulate clinical protocols. Consequently, it is well suited to establish parametric comparisons between clinical and preclinical techniques. In this study, we concentrated on two treatment sites, brain and lung, to define treatment conformality index, homogeneity, penumbra, PDD, and fractionated doses to establish a link to guide radiobiological experiments using clinical protocols as a gold standard. Results: Three and five beam irradiations were delivered to a small animal body and head phantom with radiochromic film to simulate lung and brain treatment. A three beam irradiation to the lung yielded a 625 um penumbra. Compare this value with a human treatment penumbra of 1 cm, and penumbra scales as the ratio between body sizes. The homogeneity of our system is similar to the 10% typically used in clinical treatment planning. Conclusions: By comparing preclinical and clinical treatment metrics, the extent of translation can be determined and improved, leading to better understanding of preclinical results and improved correlation with clinical procedures. This will lead to more clinically based preclinical experiments and improve translation efficiency between the two testing environments, thus providing new clinical treatment strategies and improved human cancer treatment.

AB - Purpose: The purpose of this study was to compare the techniques and protocols used in clinical radiation therapy and recently developed preclinical image guided micro irradiation to establish a link between small animal conformal irradiation and clinical treatment protocols. This work will establish protocols that, according to treatment site, will facilitate the translation of conclusions from radiobiological experiments to clinical applications, fostering the advancement of radiotherapy. Methods: Data was gathered using our small animal image guided micro irradiation device, the microIGRT, as an example of preclinical techniques which mimic equivalent clinical treatment protocols. The microIGRT utilizes fractionated treatments, multibeam irradiations, modulated beams, image guided treatment verification, and doses to emulate clinical protocols. Consequently, it is well suited to establish parametric comparisons between clinical and preclinical techniques. In this study, we concentrated on two treatment sites, brain and lung, to define treatment conformality index, homogeneity, penumbra, PDD, and fractionated doses to establish a link to guide radiobiological experiments using clinical protocols as a gold standard. Results: Three and five beam irradiations were delivered to a small animal body and head phantom with radiochromic film to simulate lung and brain treatment. A three beam irradiation to the lung yielded a 625 um penumbra. Compare this value with a human treatment penumbra of 1 cm, and penumbra scales as the ratio between body sizes. The homogeneity of our system is similar to the 10% typically used in clinical treatment planning. Conclusions: By comparing preclinical and clinical treatment metrics, the extent of translation can be determined and improved, leading to better understanding of preclinical results and improved correlation with clinical procedures. This will lead to more clinically based preclinical experiments and improve translation efficiency between the two testing environments, thus providing new clinical treatment strategies and improved human cancer treatment.

UR - http://www.scopus.com/inward/record.url?scp=85024808887&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85024808887&partnerID=8YFLogxK

U2 - 10.1118/1.4735919

DO - 10.1118/1.4735919

M3 - Article

VL - 39

SP - 3899

EP - 3900

JO - Medical Physics

JF - Medical Physics

SN - 0094-2405

IS - 6

ER -