Tumor induction by the LTR, v-src, LTR DNA in four B (MHC) congenic lines of chickens

Jan Svoboda, Jiří Plachý, Jiří Hejnar, Ivan Karakoz, Ramareddy Guntaka, Josef Geryk

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

We report that the cloned DNA harboring the long terminal repeat (LTR), v-src, LTR proviral structure is tumorigenic in chickens of the Prague congenic lines. The growth rate of these tumors is by far the highest in the recombinant CC.R1 line, the B haplotype of which is composed of the B-F/L4 and B-G12 subregions originating from different naturally occurring haplotypes. Some of the tumors induced by the LTR, v-src, LTR DNA are repeatedly transplantable in syngeneic chickens, maintain unaltered provirus, and express v-src mRNA. Differences in the response to challenge with Rous sarcoma virus (RSV) and LTR, v-src, LTR DNA on a given experimental model are compared and possible involvement of an interaction between B-F/L and B-G region gene is considered. Regression of the LTR, v-src, LTR DNA-induced tumors did not prevent the formation and growth of tumors induced subsequently by RSV.

Original languageEnglish (US)
Pages (from-to)309-315
Number of pages7
JournalImmunogenetics
Volume35
Issue number5
DOIs
StatePublished - Mar 1 1992

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Terminal Repeat Sequences
Chickens
DNA
Neoplasms
Rous sarcoma virus
Haplotypes
Proviruses
Growth
Theoretical Models
Messenger RNA

All Science Journal Classification (ASJC) codes

  • Immunology
  • Genetics

Cite this

Tumor induction by the LTR, v-src, LTR DNA in four B (MHC) congenic lines of chickens. / Svoboda, Jan; Plachý, Jiří; Hejnar, Jiří; Karakoz, Ivan; Guntaka, Ramareddy; Geryk, Josef.

In: Immunogenetics, Vol. 35, No. 5, 01.03.1992, p. 309-315.

Research output: Contribution to journalArticle

Svoboda, J, Plachý, J, Hejnar, J, Karakoz, I, Guntaka, R & Geryk, J 1992, 'Tumor induction by the LTR, v-src, LTR DNA in four B (MHC) congenic lines of chickens', Immunogenetics, vol. 35, no. 5, pp. 309-315. https://doi.org/10.1007/BF00189893
Svoboda, Jan ; Plachý, Jiří ; Hejnar, Jiří ; Karakoz, Ivan ; Guntaka, Ramareddy ; Geryk, Josef. / Tumor induction by the LTR, v-src, LTR DNA in four B (MHC) congenic lines of chickens. In: Immunogenetics. 1992 ; Vol. 35, No. 5. pp. 309-315.
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