Tumor location with 1-aminocyclopentane [11C] carboxylic acid

preliminary clinical trials with single-photon detection

Karl Hubner, G. A. Andrews, L. Washburn, B. W. Wieland, W. D. Gibbs, R. L. Hayes, T. A. Butler, J. D. Winebrenner

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

High specific activity [11C] Carboxyl-labeled 1-aminocyclopentane-carboxylic acid ([11C] ACPC) was tested as a tumor-scanning agent in thirty-eight patients. This artificial amino acid clears the blood to a level of less than 12% within 45 min; thus, imaging is possible within the useful life of C-11. [11C] ACPC can be produced in amounts adequate for clinical scanning. Doses between 12 and 45 mCi were given by i.v. injection, and scans obtained only in the single-photon mode gave clinical information on the sites of tumors. There was no evidence of any toxic effects from [11C] ACPC, and the radiation doses as extrapolated from animal data are approximately 0.01 rad per mCi for the whole body and less than 0.06 rad per mCi for the pancreas. In all but five of the 38 patients [11C] ACPC scans were compared with those obtained with Ga-67 citrate. There were 19 positive [11C] ACPC scans and 24 positive Ga-67 scans. The results indicate that [11C] ACPC is likely to be of diagnostic value for cancer patients if used in conjunction with positron tomography instrumentation.

Original languageEnglish (US)
Pages (from-to)1215-1221
Number of pages7
JournalJournal of Nuclear Medicine
Volume18
Issue number12
StatePublished - Dec 1 1977
Externally publishedYes

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Carboxylic Acids
Photons
Clinical Trials
Neoplasms
Poisons
Pancreas
Tomography
Electrons
Radiation
Amino Acids
Injections

All Science Journal Classification (ASJC) codes

  • Radiological and Ultrasound Technology

Cite this

Hubner, K., Andrews, G. A., Washburn, L., Wieland, B. W., Gibbs, W. D., Hayes, R. L., ... Winebrenner, J. D. (1977). Tumor location with 1-aminocyclopentane [11C] carboxylic acid: preliminary clinical trials with single-photon detection. Journal of Nuclear Medicine, 18(12), 1215-1221.

Tumor location with 1-aminocyclopentane [11C] carboxylic acid : preliminary clinical trials with single-photon detection. / Hubner, Karl; Andrews, G. A.; Washburn, L.; Wieland, B. W.; Gibbs, W. D.; Hayes, R. L.; Butler, T. A.; Winebrenner, J. D.

In: Journal of Nuclear Medicine, Vol. 18, No. 12, 01.12.1977, p. 1215-1221.

Research output: Contribution to journalArticle

Hubner, K, Andrews, GA, Washburn, L, Wieland, BW, Gibbs, WD, Hayes, RL, Butler, TA & Winebrenner, JD 1977, 'Tumor location with 1-aminocyclopentane [11C] carboxylic acid: preliminary clinical trials with single-photon detection', Journal of Nuclear Medicine, vol. 18, no. 12, pp. 1215-1221.
Hubner, Karl ; Andrews, G. A. ; Washburn, L. ; Wieland, B. W. ; Gibbs, W. D. ; Hayes, R. L. ; Butler, T. A. ; Winebrenner, J. D. / Tumor location with 1-aminocyclopentane [11C] carboxylic acid : preliminary clinical trials with single-photon detection. In: Journal of Nuclear Medicine. 1977 ; Vol. 18, No. 12. pp. 1215-1221.
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