Twenty-four-hour intragastric acidity and nocturnal gastric secretion in gastric ulcer patients - the effects of cimetidine

J. K. Derodra, Colin Howden, D. W. Burget, R. H. Hunt

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

In a double-blind randomized study, the profile of 24-h intragastric acidity and nocturnal gastric secretion was measured in a group of patients with healed gastric ulcer on placebo and 400 mg cimetidine b.d. and 800 mg nocte. Neither cimetidine regimen significantly decreased daytime intragastric acidity, but the 800 mg nocte dose caused a significant decrease in both nocturnal acidity (18.1 to 5.5 mmol/L; P < 0.05) and acid output (11.0 to 1.7 mmol 7 h; P < 0.05). The decrease in nocturnal gastric secretion by 400 mg cimetidine b.d. was not significant. As in duodenal ulcer, 800 mg cimetidine nocte will effectively suppress night-time acid secretion in patients with gastric ulcer while leaving acid secretion during the day unaffected.

Original languageEnglish (US)
Pages (from-to)275-281
Number of pages7
JournalAlimentary Pharmacology and Therapeutics
Volume4
Issue number3
StatePublished - 1990
Externally publishedYes

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Cimetidine
Stomach Ulcer
Stomach
Acids
Duodenal Ulcer
Double-Blind Method
Placebos

All Science Journal Classification (ASJC) codes

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

Twenty-four-hour intragastric acidity and nocturnal gastric secretion in gastric ulcer patients - the effects of cimetidine. / Derodra, J. K.; Howden, Colin; Burget, D. W.; Hunt, R. H.

In: Alimentary Pharmacology and Therapeutics, Vol. 4, No. 3, 1990, p. 275-281.

Research output: Contribution to journalArticle

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