Twenty-four-hour intragastric acidity in duodenal ulcer patients during dosing with placebo, and 150 mg ranitidine twice or four times daily

Colin Howden, H. H. Tsai, J. L. Reid

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11 Citations (Scopus)

Abstract

Twenty-four-hour intragastric acidity was measured in 10 patients with a past history of duodenal ulcer on the fourth day of dosing with placebo, and either 150 mg ranitidine given twice or four times daily. The order of the treatments was randomized and a double-blind design was employed. Ranitidine (150 mg) b.d. decreased median integrated 24-h intragastric acidity by 65.1%, noctural acidity by 89.1%, and daytime acidity by 54.6% (all P <0.01 compared to placebo). The corresponding decreases with 150 mg ranitidine q.d.s. were 62.3, 89.9 and 48.8%, respectively (all P <0.01 compared to placebo). There were no significant differences between the two dosage regimens of ranitidine (P>0.05). This study shows that giving extra doses of 150 mg ranitidine during the day does not increase the degree of suppression of intragastric acidity.

Original languageEnglish (US)
Pages (from-to)253-258
Number of pages6
JournalAlimentary Pharmacology and Therapeutics
Volume3
Issue number3
StatePublished - Dec 1 1989
Externally publishedYes

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Ranitidine
Duodenal Ulcer
Placebos
Therapeutics

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology
  • Pharmacology (medical)

Cite this

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title = "Twenty-four-hour intragastric acidity in duodenal ulcer patients during dosing with placebo, and 150 mg ranitidine twice or four times daily",
abstract = "Twenty-four-hour intragastric acidity was measured in 10 patients with a past history of duodenal ulcer on the fourth day of dosing with placebo, and either 150 mg ranitidine given twice or four times daily. The order of the treatments was randomized and a double-blind design was employed. Ranitidine (150 mg) b.d. decreased median integrated 24-h intragastric acidity by 65.1{\%}, noctural acidity by 89.1{\%}, and daytime acidity by 54.6{\%} (all P <0.01 compared to placebo). The corresponding decreases with 150 mg ranitidine q.d.s. were 62.3, 89.9 and 48.8{\%}, respectively (all P <0.01 compared to placebo). There were no significant differences between the two dosage regimens of ranitidine (P>0.05). This study shows that giving extra doses of 150 mg ranitidine during the day does not increase the degree of suppression of intragastric acidity.",
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AU - Howden, Colin

AU - Tsai, H. H.

AU - Reid, J. L.

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N2 - Twenty-four-hour intragastric acidity was measured in 10 patients with a past history of duodenal ulcer on the fourth day of dosing with placebo, and either 150 mg ranitidine given twice or four times daily. The order of the treatments was randomized and a double-blind design was employed. Ranitidine (150 mg) b.d. decreased median integrated 24-h intragastric acidity by 65.1%, noctural acidity by 89.1%, and daytime acidity by 54.6% (all P <0.01 compared to placebo). The corresponding decreases with 150 mg ranitidine q.d.s. were 62.3, 89.9 and 48.8%, respectively (all P <0.01 compared to placebo). There were no significant differences between the two dosage regimens of ranitidine (P>0.05). This study shows that giving extra doses of 150 mg ranitidine during the day does not increase the degree of suppression of intragastric acidity.

AB - Twenty-four-hour intragastric acidity was measured in 10 patients with a past history of duodenal ulcer on the fourth day of dosing with placebo, and either 150 mg ranitidine given twice or four times daily. The order of the treatments was randomized and a double-blind design was employed. Ranitidine (150 mg) b.d. decreased median integrated 24-h intragastric acidity by 65.1%, noctural acidity by 89.1%, and daytime acidity by 54.6% (all P <0.01 compared to placebo). The corresponding decreases with 150 mg ranitidine q.d.s. were 62.3, 89.9 and 48.8%, respectively (all P <0.01 compared to placebo). There were no significant differences between the two dosage regimens of ranitidine (P>0.05). This study shows that giving extra doses of 150 mg ranitidine during the day does not increase the degree of suppression of intragastric acidity.

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