Two consistently deleted regions within chromosome 1p32-pter in human non-small cell lung cancer

Viktor Chizhikov, Irina Zborovskaya, Konstantin Laktionov, Vera Delektorskaya, Boris Polotskii, Alexander Tatosyan, Alexander Gasparian

Research output: Contribution to journalArticle

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Abstract

Allelic losses at 1p32-pter have been reported as frequent events in human non-small cell lung cancer (NSCLC). To further characterize the region of deletions, we studied loss of heterozygosity on a panel of 102 microdissected NSCLC samples with 20 polymorphic markers spanning 1p32-pter. Two shortest regions of the overlap of the deletions (SROs) were found: SRO 2a (D1S417-D1S57) and SRO 2b (D1S450-D1S243). Allelic losses at either region correlated independently with advanced stage of disease and with postoperative metastasis and relapse (P < 0.05), suggesting that crucial genes in these regions are involved in NSCLC progression.

Original languageEnglish (US)
Pages (from-to)151-158
Number of pages8
JournalMolecular Carcinogenesis
Volume30
Issue number3
DOIs
StatePublished - Apr 18 2001
Externally publishedYes

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Loss of Heterozygosity
Non-Small Cell Lung Carcinoma
Chromosomes
Neoplasm Metastasis
Recurrence
Genes

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cancer Research

Cite this

Chizhikov, V., Zborovskaya, I., Laktionov, K., Delektorskaya, V., Polotskii, B., Tatosyan, A., & Gasparian, A. (2001). Two consistently deleted regions within chromosome 1p32-pter in human non-small cell lung cancer. Molecular Carcinogenesis, 30(3), 151-158. https://doi.org/10.1002/mc.1023

Two consistently deleted regions within chromosome 1p32-pter in human non-small cell lung cancer. / Chizhikov, Viktor; Zborovskaya, Irina; Laktionov, Konstantin; Delektorskaya, Vera; Polotskii, Boris; Tatosyan, Alexander; Gasparian, Alexander.

In: Molecular Carcinogenesis, Vol. 30, No. 3, 18.04.2001, p. 151-158.

Research output: Contribution to journalArticle

Chizhikov, V, Zborovskaya, I, Laktionov, K, Delektorskaya, V, Polotskii, B, Tatosyan, A & Gasparian, A 2001, 'Two consistently deleted regions within chromosome 1p32-pter in human non-small cell lung cancer', Molecular Carcinogenesis, vol. 30, no. 3, pp. 151-158. https://doi.org/10.1002/mc.1023
Chizhikov V, Zborovskaya I, Laktionov K, Delektorskaya V, Polotskii B, Tatosyan A et al. Two consistently deleted regions within chromosome 1p32-pter in human non-small cell lung cancer. Molecular Carcinogenesis. 2001 Apr 18;30(3):151-158. https://doi.org/10.1002/mc.1023
Chizhikov, Viktor ; Zborovskaya, Irina ; Laktionov, Konstantin ; Delektorskaya, Vera ; Polotskii, Boris ; Tatosyan, Alexander ; Gasparian, Alexander. / Two consistently deleted regions within chromosome 1p32-pter in human non-small cell lung cancer. In: Molecular Carcinogenesis. 2001 ; Vol. 30, No. 3. pp. 151-158.
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