Two long QT syndrome loci map to chromosomes 3 and 7 with evidence for further heterogeneity

Changan Jiang, Donald Atkinson, Jeffrey Towbin, Igor Splawski, Michael H. Lehmann, Hua Li, Katherine Timothy, R. Thomas Taggart, Peter J. Schwartz, G. Michael Vincent, Arthur J. Moss, Mark T. Keating

Research output: Contribution to journalArticle

234 Citations (Scopus)

Abstract

Cardiac arrhythmias cause sudden death in 300, 000 United States citizens every year. In this study, we describe two new loci for an inherited cardiac arrhythmia, long QT syndrome (LQT). In 1991 we reported linkage of LQT to chromosome 11 p15.5. In this study we demonstrate further linkage to D7S483 in nine families with a combined lod score of 19.41 and to D3S1100 in three families with a combined score of 6.72. These findings localize major LQT genes to chromosomes 7q35–36 and 3p21–24, respectively. Linkage to any known locus was excluded in three families indicating that additional heterogeneity exists. Proteins encoded by different LQT genes may interact to modulate cardiac repolarization and arrhythmia risk.

Original languageEnglish (US)
Pages (from-to)141-147
Number of pages7
JournalNature Genetics
Volume8
Issue number2
DOIs
StatePublished - Jan 1 1994
Externally publishedYes

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Long QT Syndrome
Chromosomes, Human, Pair 3
Chromosomes, Human, Pair 7
Cardiac Arrhythmias
Lod Score
Chromosomes, Human, Pair 11
Sudden Death
Genes
Cause of Death
Chromosomes
Proteins

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

Jiang, C., Atkinson, D., Towbin, J., Splawski, I., Lehmann, M. H., Li, H., ... Keating, M. T. (1994). Two long QT syndrome loci map to chromosomes 3 and 7 with evidence for further heterogeneity. Nature Genetics, 8(2), 141-147. https://doi.org/10.1038/ng1094-141

Two long QT syndrome loci map to chromosomes 3 and 7 with evidence for further heterogeneity. / Jiang, Changan; Atkinson, Donald; Towbin, Jeffrey; Splawski, Igor; Lehmann, Michael H.; Li, Hua; Timothy, Katherine; Taggart, R. Thomas; Schwartz, Peter J.; Vincent, G. Michael; Moss, Arthur J.; Keating, Mark T.

In: Nature Genetics, Vol. 8, No. 2, 01.01.1994, p. 141-147.

Research output: Contribution to journalArticle

Jiang, C, Atkinson, D, Towbin, J, Splawski, I, Lehmann, MH, Li, H, Timothy, K, Taggart, RT, Schwartz, PJ, Vincent, GM, Moss, AJ & Keating, MT 1994, 'Two long QT syndrome loci map to chromosomes 3 and 7 with evidence for further heterogeneity', Nature Genetics, vol. 8, no. 2, pp. 141-147. https://doi.org/10.1038/ng1094-141
Jiang, Changan ; Atkinson, Donald ; Towbin, Jeffrey ; Splawski, Igor ; Lehmann, Michael H. ; Li, Hua ; Timothy, Katherine ; Taggart, R. Thomas ; Schwartz, Peter J. ; Vincent, G. Michael ; Moss, Arthur J. ; Keating, Mark T. / Two long QT syndrome loci map to chromosomes 3 and 7 with evidence for further heterogeneity. In: Nature Genetics. 1994 ; Vol. 8, No. 2. pp. 141-147.
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