Type I interferon production enhances susceptibility to Listeria monocytogenes infection

Ryan M. O'Connell, Supriya K. Saha, Sagar A. Vaidya, Kevin W. Bruhn, Gustavo Miranda-Carboni, Brian Zarnegar, Andrea K. Perry, Bidong O. Nguyen, Timothy F. Lane, Tadatsugu Taniguchi, Jeff F. Miller, Genhong Cheng

Research output: Contribution to journalArticle

359 Citations (Scopus)

Abstract

Numerous bacterial products such as lipopolysaccharide potently induce type I interferons (IFNs); however, the contribution of this innate response to host defense against bacterial infection remains unclear. Although mice deficient in either IFN regulatory factor (IRF)3 or the type I IFN receptor (IFNAR)1 are highly susceptible to viral infection, we show that these mice exhibit a profound resistance to infection caused by the Gram-positive intracellular bacterium Listeria monocytogenes compared with wild-type controls. Furthermore, this enhanced bacterial clearance is accompanied by a block in L. monocytogenes-induced splenic apoptosis in IRF3- and IFNAR1-deficient mice. Thus, our results highlight the disparate roles of type I IFNs during bacterial versus viral infections and stress the importance of proper IFN modulation in host defense.

Original languageEnglish (US)
Pages (from-to)437-445
Number of pages9
JournalJournal of Experimental Medicine
Volume200
Issue number4
DOIs
StatePublished - Aug 16 2004
Externally publishedYes

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Listeriosis
Interferon Type I
Listeria monocytogenes
Virus Diseases
Interferon alpha-beta Receptor
Interferon Regulatory Factor-3
Gram-Positive Bacteria
Bacterial Infections
Interferons
Lipopolysaccharides
Apoptosis
Infection

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

Type I interferon production enhances susceptibility to Listeria monocytogenes infection. / O'Connell, Ryan M.; Saha, Supriya K.; Vaidya, Sagar A.; Bruhn, Kevin W.; Miranda-Carboni, Gustavo; Zarnegar, Brian; Perry, Andrea K.; Nguyen, Bidong O.; Lane, Timothy F.; Taniguchi, Tadatsugu; Miller, Jeff F.; Cheng, Genhong.

In: Journal of Experimental Medicine, Vol. 200, No. 4, 16.08.2004, p. 437-445.

Research output: Contribution to journalArticle

O'Connell, RM, Saha, SK, Vaidya, SA, Bruhn, KW, Miranda-Carboni, G, Zarnegar, B, Perry, AK, Nguyen, BO, Lane, TF, Taniguchi, T, Miller, JF & Cheng, G 2004, 'Type I interferon production enhances susceptibility to Listeria monocytogenes infection', Journal of Experimental Medicine, vol. 200, no. 4, pp. 437-445. https://doi.org/10.1084/jem.20040712
O'Connell, Ryan M. ; Saha, Supriya K. ; Vaidya, Sagar A. ; Bruhn, Kevin W. ; Miranda-Carboni, Gustavo ; Zarnegar, Brian ; Perry, Andrea K. ; Nguyen, Bidong O. ; Lane, Timothy F. ; Taniguchi, Tadatsugu ; Miller, Jeff F. ; Cheng, Genhong. / Type I interferon production enhances susceptibility to Listeria monocytogenes infection. In: Journal of Experimental Medicine. 2004 ; Vol. 200, No. 4. pp. 437-445.
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