Type II collagen-induced arthritis in mice. IV. Variations in immunogenetic regulation provide evidence for multiple arthritogenic epitopes on the collagen molecule

P. H. Wooley, H. S. Luthra, M. M. Griffiths, John Stuart, A. Huse, C. S. David

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Abstract

Type II collagen from six mammalian species was investigated for the capacity to induce an immune response and collagen-induced arthritis (CIA) n C57/B10 congenic mouse strains. H-2(q) haplotype mice were susceptible to chick, bovine, deer, rat, and human type II collagen, but were resistant to arthritis induced by porcine type II collagen. H-2(r) haplotype mice only developed CIA in response to bovine, deer, and porcine collagen. High antibody responses in the absence of disease, directed against a specific type II collagen, were observed in many independent haplotypes. The cross-reactive capacity of different antisera to the various collagen species was studied. The data support the existence of two arthritogenic and multiple nonarthritogenic epitopes on the type II collagen molecule.

Original languageEnglish (US)
Pages (from-to)2443-2451
Number of pages9
JournalJournal of Immunology
Volume135
Issue number4
StatePublished - Dec 1 1985

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Immunogenetics
Experimental Arthritis
Collagen Type II
Epitopes
Collagen
Haplotypes
Deer
Swine
Congenic Mice
Arthritis
Antibody Formation
Immune Sera

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

Type II collagen-induced arthritis in mice. IV. Variations in immunogenetic regulation provide evidence for multiple arthritogenic epitopes on the collagen molecule. / Wooley, P. H.; Luthra, H. S.; Griffiths, M. M.; Stuart, John; Huse, A.; David, C. S.

In: Journal of Immunology, Vol. 135, No. 4, 01.12.1985, p. 2443-2451.

Research output: Contribution to journalArticle

Wooley, P. H. ; Luthra, H. S. ; Griffiths, M. M. ; Stuart, John ; Huse, A. ; David, C. S. / Type II collagen-induced arthritis in mice. IV. Variations in immunogenetic regulation provide evidence for multiple arthritogenic epitopes on the collagen molecule. In: Journal of Immunology. 1985 ; Vol. 135, No. 4. pp. 2443-2451.
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