Type II collagen-induced autoimmune otospongiosis

A preliminary report

T. J. Yoo, K. Tomoda, Andrew Kang, J. M. Stuart, A. S. Townes

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Otospongiosis-like lesions were induced in rats by immunizing them with native type II collagen. Immunized rats had antibody responses specific for native type II collagen and developed otospongiosis-like lesions. The spongiotic lesion was characterized by numerous osteocytes and osteoblasts in the vascular spaces and by dark staining probably due to the chemical alteration of ground substances. Bone resorption and new bone formation were clearly visible. Immunofluorescence studies demonstrated deposition of immunoglobulin and complement on the bone matrix and wall within the area of spongiosis. An antibody-mediated etiopathogenesis was suspected.

Original languageEnglish (US)
Pages (from-to)103-108
Number of pages6
JournalAnnals of Otology, Rhinology & Laryngology
Volume92
Issue number2
DOIs
StatePublished - Jan 1 1983

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Otosclerosis
Collagen Type II
Osteocytes
Bone Matrix
Bone Resorption
Osteoblasts
Osteogenesis
Antibody Formation
Fluorescent Antibody Technique
Blood Vessels
Immunoglobulins
Staining and Labeling
Antibodies

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology
  • Medicine(all)

Cite this

Type II collagen-induced autoimmune otospongiosis : A preliminary report. / Yoo, T. J.; Tomoda, K.; Kang, Andrew; Stuart, J. M.; Townes, A. S.

In: Annals of Otology, Rhinology & Laryngology, Vol. 92, No. 2, 01.01.1983, p. 103-108.

Research output: Contribution to journalArticle

Yoo, T. J. ; Tomoda, K. ; Kang, Andrew ; Stuart, J. M. ; Townes, A. S. / Type II collagen-induced autoimmune otospongiosis : A preliminary report. In: Annals of Otology, Rhinology & Laryngology. 1983 ; Vol. 92, No. 2. pp. 103-108.
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