Type II collagen-induced autoimmune salpingitis in rats

K. Tomoda, T. J. Yoo, J. Stuart

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Autoimmune salpingitis was induced in 17 (85%) of 20 outbred Wistar rats by immunization with bovine type II collagen; three of those also developed eustachian tube chondritis. The lesions were characterized by infiltrations of a large number of mononuclear cells in the mucosa and submucosa, destruction of cartilaginous structure, and deposition of IgG and complement C3. The animals had high titers of anti-type II collagen antibody. Immunohistochemical examination using monoclonal antibody to type II collagen revealed the presence of type II collagen in the eustachian tube cartilage. These observations suggest a causal relationship between autoimmunity to type II collagen and salpingitis in the rat, and this animal model may be useful in defining the pathogenesis of eustachian tube diseases mediated by immunity to type II collagen.

Original languageEnglish (US)
Pages (from-to)156-161
Number of pages6
JournalAnnals of Otology, Rhinology and Laryngology
Volume94
Issue number2 I
DOIs
StatePublished - Jan 1 1985

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Salpingitis
Collagen Type II
Eustachian Tube
Complement C3
Autoimmunity
Cartilage
Wistar Rats
Immunity
Immunization
Mucous Membrane
Animal Models
Cell Count
Immunoglobulin G
Monoclonal Antibodies
Antibodies

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology

Cite this

Type II collagen-induced autoimmune salpingitis in rats. / Tomoda, K.; Yoo, T. J.; Stuart, J.

In: Annals of Otology, Rhinology and Laryngology, Vol. 94, No. 2 I, 01.01.1985, p. 156-161.

Research output: Contribution to journalArticle

Tomoda, K. ; Yoo, T. J. ; Stuart, J. / Type II collagen-induced autoimmune salpingitis in rats. In: Annals of Otology, Rhinology and Laryngology. 1985 ; Vol. 94, No. 2 I. pp. 156-161.
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