Type II collagen-induced autoimmune sensorineural hearing loss and vestibular dysfunction in rats

T. J. Yoo, M. A. Cremer, K. Tomoda, A. S. Townes, John Stuart, Andrew Kang

Research output: Contribution to journalArticle

111 Citations (Scopus)

Abstract

Autoimmune sensorineural hearing loss was induced in rats by immunizing them with native bovine type II collagen. Type I and denatured type II collagen, administered by an identical immunization procedure, would not induce disease. Evidence of sensorineural hearing loss was obtained by measuring the brainstem evoked potential and by observing histopathologic changes consisting of cochlear nerve degeneration and perineural vasculitis in affected animals. Immunized animals had high levels of antibodies to native type II collagen.

Original languageEnglish (US)
Pages (from-to)267-271
Number of pages5
JournalAnnals of Otology, Rhinology & Laryngology
Volume92
Issue number3
DOIs
StatePublished - Jan 1 1983

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Collagen Type II
Sensorineural Hearing Loss
Nerve Degeneration
Cochlear Nerve
Vasculitis
Evoked Potentials
Brain Stem
Immunization
Antibodies

All Science Journal Classification (ASJC) codes

  • Otorhinolaryngology
  • Medicine(all)

Cite this

Type II collagen-induced autoimmune sensorineural hearing loss and vestibular dysfunction in rats. / Yoo, T. J.; Cremer, M. A.; Tomoda, K.; Townes, A. S.; Stuart, John; Kang, Andrew.

In: Annals of Otology, Rhinology & Laryngology, Vol. 92, No. 3, 01.01.1983, p. 267-271.

Research output: Contribution to journalArticle

Yoo, T. J. ; Cremer, M. A. ; Tomoda, K. ; Townes, A. S. ; Stuart, John ; Kang, Andrew. / Type II collagen-induced autoimmune sensorineural hearing loss and vestibular dysfunction in rats. In: Annals of Otology, Rhinology & Laryngology. 1983 ; Vol. 92, No. 3. pp. 267-271.
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