Type-specific protective immunity evoked by synthetic peptide of Streptococcus pyogenes M protein

Edwin H. Beachey, Jerome M. Seyer, James Dale, W. Andrew Simpson, Andrew Kang

Research output: Contribution to journalArticle

109 Citations (Scopus)

Abstract

The M protein on the surface of Streptococcus pyogenes cells enables the organisms to resist ingestion and killing by phagocytic cells in the blood of the non-immune host. In the immune host, type-specific antibodies against the M protein neutralize the antiphagocytic effect and allow the rapid elimination of any invading streptococcci having the same serotype of M protein. Recent studies1 in our laboratories of the primary structure of one of these M proteins (type 24) have indicated that the molecule is composed of repeating covalent structures, each of which contains protective antigenic determinants. These results suggest that only a small portion of the M protein molecule may be required to produce primary protective immunity against S. pyogenes. We now report that this notion is well founded. Our findings may have a bearing on the development of M-protein vaccines to protect against streptococcal infections causing acute rheumatic fever and rheumatic heart disease2.

Original languageEnglish (US)
Pages (from-to)457-459
Number of pages3
JournalNature
Volume292
Issue number5822
DOIs
StatePublished - Dec 1 1981

Fingerprint

Streptococcus pyogenes
Immunity
Peptides
Proteins
Streptococcal Infections
Rheumatic Fever
Phagocytes
Epitopes
Membrane Proteins
Vaccines
Eating
Antibodies

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • General

Cite this

Type-specific protective immunity evoked by synthetic peptide of Streptococcus pyogenes M protein. / Beachey, Edwin H.; Seyer, Jerome M.; Dale, James; Simpson, W. Andrew; Kang, Andrew.

In: Nature, Vol. 292, No. 5822, 01.12.1981, p. 457-459.

Research output: Contribution to journalArticle

Beachey, Edwin H. ; Seyer, Jerome M. ; Dale, James ; Simpson, W. Andrew ; Kang, Andrew. / Type-specific protective immunity evoked by synthetic peptide of Streptococcus pyogenes M protein. In: Nature. 1981 ; Vol. 292, No. 5822. pp. 457-459.
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