Ulipristal Acetate

Contraceptive or Contragestive?

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Ulipristal acetate is the first selective progesterone receptor modulator approved for postcoital contraception in the US. It appears to be significantly more effective in inhibition of ovulation than other forms of emergency contraception. However, ulipristal acetate is structurally similar to mifepristone, and several lines of evidence suggest that a postfertilization mechanism of action is also operative. This mechanism of action is considered to be contragestive versus contraceptive. Ulipristal acetate administration is contraindicated in a known or suspected pregnancy; however, it could quite possibly be used as an effective abortifacient. Health-care providers should inform patients of the possibility of both mechanisms of action with use of this drug.

Original languageEnglish (US)
Pages (from-to)813-815
Number of pages3
JournalAnnals of Pharmacotherapy
Volume45
Issue number6
DOIs
StatePublished - Jun 1 2011

Fingerprint

Contraceptive Agents
Postcoital Contraception
Ovulation Inhibition
Abortifacient Agents
Mifepristone
Progesterone Receptors
Health Personnel
Pregnancy
Pharmaceutical Preparations
ulipristal acetate

All Science Journal Classification (ASJC) codes

  • Pharmacology (medical)

Cite this

Ulipristal Acetate : Contraceptive or Contragestive? / Keenan, Jeffrey.

In: Annals of Pharmacotherapy, Vol. 45, No. 6, 01.06.2011, p. 813-815.

Research output: Contribution to journalArticle

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