Ultrafiltration in heart failure with preserved ejection fraction comparison with systolic heart failure patients

John Jefferies, Cheryl Bartone, Santosh Menon, Gregory F. Egnaczyk, Thomas M. O'Brien, Eugene S. Chung

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Background-Ultrafiltration (UF) is a widely used technology for inpatient management of acute decompensated heart failure in patients with volume overload. However, the safety and efficacy of UF in patients with heart failure and preserved left ventricular ejection fraction (heart failure with preserved ejection fraction [HFPEF]) need further clarification. We hypothesized that UF could be used in this population with outcomes similar to acute decompensated heart failure patients with low left ventricular ejection fraction (HFLEF). Methods and Results-Prospective evaluation was performed on 2 patient cohorts admitted to a single institution for acute decompensated heart failure and treated with UF: HFLEF (left ventricular ejection fraction ≤40%; n=87) and HFPEF (left ventricular ejection fraction >40%; n=97). Selected demographic and clinical data were compared, including clinical and serological information, as well as in-hospital and 90-day postdischarge mortality. HFPEF patients were more likely to be women, have higher blood pressures, and less likely to have ischemic heart disease. There were no significant differences in total weight loss (7.7% in HFLEF and 7.0% in HFPEF), electrolyte and renal disturbances, or in-hospital mortality (3.4% in HFLEF and 3.3% in HFPEF) between the 2 groups. Mortality at 90 days tended to be greater in HFLEF (24.1%) than in HFPEF (15.5%). Conclusions-Therapeutic responses in patients with HFPEF meeting current indication for UF are similar to those with HFLEF. Larger studies are warranted to better characterize acute heart failure management with UF in this population.

Original languageEnglish (US)
Pages (from-to)733-739
Number of pages7
JournalCirculation: Heart Failure
Volume6
Issue number4
DOIs
StatePublished - Jul 1 2013
Externally publishedYes

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Systolic Heart Failure
Ultrafiltration
Heart Failure
Stroke Volume
Mortality
Hospital Mortality
Electrolytes
Population
Myocardial Ischemia
Weight Loss
Inpatients

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Ultrafiltration in heart failure with preserved ejection fraction comparison with systolic heart failure patients. / Jefferies, John; Bartone, Cheryl; Menon, Santosh; Egnaczyk, Gregory F.; O'Brien, Thomas M.; Chung, Eugene S.

In: Circulation: Heart Failure, Vol. 6, No. 4, 01.07.2013, p. 733-739.

Research output: Contribution to journalArticle

Jefferies, John ; Bartone, Cheryl ; Menon, Santosh ; Egnaczyk, Gregory F. ; O'Brien, Thomas M. ; Chung, Eugene S. / Ultrafiltration in heart failure with preserved ejection fraction comparison with systolic heart failure patients. In: Circulation: Heart Failure. 2013 ; Vol. 6, No. 4. pp. 733-739.
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