Ultrasound exposure results in up-regulation of sulfated protein production in chondrocytes

Paul Lee, Jae Rho, Karen Hasty

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The effects of ultrasound energy on chondrocyte production of sulfated proteins (glycoaminoglycans) were investigated. Measurements of sulfated protein were significantly higher but cell proliferation was not greater for treated cells as compared to controls. The increase in sulfated protein in test cells was due to up-regulation of production by the cells rather than an increase in cell number. The observed cellular response appeared to be dose-dependent. The results hold promise for the improvement of tissue-engineered cartilage. Chondrocytes might be simulated to produce cartilage more efficiently by the application of ultrasound to cell-seeded polymer scaffold constructs.

Original languageEnglish (US)
Title of host publicationSouthern Biomedical Engineering Conference - Proceedings
PublisherIEEE
Pages95
Number of pages1
StatePublished - 1998
Externally publishedYes
EventProceedings of the 1998 17th Southern Biomedical Engineering Conference - San Antonio, TX, USA
Duration: Feb 6 1998Feb 8 1998

Other

OtherProceedings of the 1998 17th Southern Biomedical Engineering Conference
CitySan Antonio, TX, USA
Period2/6/982/8/98

Fingerprint

Ultrasonics
Cartilage
Proteins
Cell proliferation
Scaffolds
Cells
Tissue
Polymers

All Science Journal Classification (ASJC) codes

  • Engineering(all)

Cite this

Lee, P., Rho, J., & Hasty, K. (1998). Ultrasound exposure results in up-regulation of sulfated protein production in chondrocytes. In Southern Biomedical Engineering Conference - Proceedings (pp. 95). IEEE.

Ultrasound exposure results in up-regulation of sulfated protein production in chondrocytes. / Lee, Paul; Rho, Jae; Hasty, Karen.

Southern Biomedical Engineering Conference - Proceedings. IEEE, 1998. p. 95.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Lee, P, Rho, J & Hasty, K 1998, Ultrasound exposure results in up-regulation of sulfated protein production in chondrocytes. in Southern Biomedical Engineering Conference - Proceedings. IEEE, pp. 95, Proceedings of the 1998 17th Southern Biomedical Engineering Conference, San Antonio, TX, USA, 2/6/98.
Lee P, Rho J, Hasty K. Ultrasound exposure results in up-regulation of sulfated protein production in chondrocytes. In Southern Biomedical Engineering Conference - Proceedings. IEEE. 1998. p. 95
Lee, Paul ; Rho, Jae ; Hasty, Karen. / Ultrasound exposure results in up-regulation of sulfated protein production in chondrocytes. Southern Biomedical Engineering Conference - Proceedings. IEEE, 1998. pp. 95
@inproceedings{f3db9ae0fdd647788679a1305baa2de3,
title = "Ultrasound exposure results in up-regulation of sulfated protein production in chondrocytes",
abstract = "The effects of ultrasound energy on chondrocyte production of sulfated proteins (glycoaminoglycans) were investigated. Measurements of sulfated protein were significantly higher but cell proliferation was not greater for treated cells as compared to controls. The increase in sulfated protein in test cells was due to up-regulation of production by the cells rather than an increase in cell number. The observed cellular response appeared to be dose-dependent. The results hold promise for the improvement of tissue-engineered cartilage. Chondrocytes might be simulated to produce cartilage more efficiently by the application of ultrasound to cell-seeded polymer scaffold constructs.",
author = "Paul Lee and Jae Rho and Karen Hasty",
year = "1998",
language = "English (US)",
pages = "95",
booktitle = "Southern Biomedical Engineering Conference - Proceedings",
publisher = "IEEE",

}

TY - GEN

T1 - Ultrasound exposure results in up-regulation of sulfated protein production in chondrocytes

AU - Lee, Paul

AU - Rho, Jae

AU - Hasty, Karen

PY - 1998

Y1 - 1998

N2 - The effects of ultrasound energy on chondrocyte production of sulfated proteins (glycoaminoglycans) were investigated. Measurements of sulfated protein were significantly higher but cell proliferation was not greater for treated cells as compared to controls. The increase in sulfated protein in test cells was due to up-regulation of production by the cells rather than an increase in cell number. The observed cellular response appeared to be dose-dependent. The results hold promise for the improvement of tissue-engineered cartilage. Chondrocytes might be simulated to produce cartilage more efficiently by the application of ultrasound to cell-seeded polymer scaffold constructs.

AB - The effects of ultrasound energy on chondrocyte production of sulfated proteins (glycoaminoglycans) were investigated. Measurements of sulfated protein were significantly higher but cell proliferation was not greater for treated cells as compared to controls. The increase in sulfated protein in test cells was due to up-regulation of production by the cells rather than an increase in cell number. The observed cellular response appeared to be dose-dependent. The results hold promise for the improvement of tissue-engineered cartilage. Chondrocytes might be simulated to produce cartilage more efficiently by the application of ultrasound to cell-seeded polymer scaffold constructs.

UR - http://www.scopus.com/inward/record.url?scp=0031654891&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031654891&partnerID=8YFLogxK

M3 - Conference contribution

SP - 95

BT - Southern Biomedical Engineering Conference - Proceedings

PB - IEEE

ER -