Understanding fibrosis in eosinophilic esophagitis

Are we there yet?

Jennifer Armbruster-Lee, Cary P. Cavender, Jay Lieberman, Amali Samarasinghe

Research output: Contribution to journalReview article

Abstract

Eosinophilic esophagitis (EoE) is an immune/antigen-mediated, progressive fibrostenotic disease characterized by symptoms of esophageal dysfunction and abnormal eosinophilic infiltration in the esophagus. Despite current treatment modalities of dietary antigen elimination or topical corticosteroids, a subset of patients do not have clinical or histologic response. Even with resolution of superficial epithelial eosinophilia, patients may still have progressive subepithelial fibrosis, which may lead to esophageal strictures over time. Histologic identification of subepithelial fibrosis requires deep esophageal biopsies, which are not routinely obtained. Herein, we review the challenges in diagnosing and treating fibrosis in EoE. We propose the novel concept of vitamin D supplementation to treat fibrosis in EoE through downregulation of profibrotic mediator, transforming growth factor-beta.

Original languageEnglish (US)
Pages (from-to)31-40
Number of pages10
JournalJournal of Leukocyte Biology
Volume104
Issue number1
DOIs
StatePublished - Jul 1 2018

Fingerprint

Eosinophilic Esophagitis
Fibrosis
Antigens
Esophageal Stenosis
Eosinophilia
Vitamin D
Transforming Growth Factor beta
Esophagus
Adrenal Cortex Hormones
Down-Regulation
Biopsy

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Cell Biology

Cite this

Understanding fibrosis in eosinophilic esophagitis : Are we there yet? / Armbruster-Lee, Jennifer; Cavender, Cary P.; Lieberman, Jay; Samarasinghe, Amali.

In: Journal of Leukocyte Biology, Vol. 104, No. 1, 01.07.2018, p. 31-40.

Research output: Contribution to journalReview article

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