Understanding the Role of Exercise in Cancer Cachexia Therapy

Justin P. Hardee, Brittany R. Counts, James Carson

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Cachexia, the unintentional loss of body weight, is prevalent in many cancer types, and the associated skeletal muscle mass depletion increases patient morbidity and mortality. While anorexia can be present, cachexia is not reversible with nutritional therapies alone. Pharmacological agents have been proposed to treat this condition, but there are currently no approved treatments. Nonetheless, the hallmark characteristics associated with cancer cachexia remain viable foundations for future therapies. Regular physical activity holds a promising future as a nonpharmacological alternative to improve patient survival through cachexia prevention. Evidence suggests exercise training is beneficial during cancer treatment and survival. However, the mechanistic examination of cachectic skeletal muscle’s response to exercise is both needed and justified. The primary objective of this review is to discuss the role of exercise for the prevention and treatment of cancer-associated muscle wasting. Initially, we provide an overview of systemic alterations induced by cancer and their role in the regulation of wasting processes during cachexia progression. We then discuss how exercise could alter disrupted regulatory pathways related to growth and metabolism during cancer-induced muscle atrophy. Last, we outline current exercise prescription guidelines and how exercise could be a potential behavioral therapy to curtail cachexia development in cancer patients.

Original languageEnglish (US)
Pages (from-to)46-60
Number of pages15
JournalAmerican Journal of Lifestyle Medicine
Volume13
Issue number1
DOIs
StatePublished - Jan 1 2019

Fingerprint

Cachexia
Exercise
Muscle Neoplasms
Neoplasms
Therapeutics
Skeletal Muscle
Survival
Muscular Atrophy
Anorexia
Prescriptions
Body Weight
Pharmacology
Guidelines
Morbidity
Mortality
Growth

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Health Policy
  • Public Health, Environmental and Occupational Health

Cite this

Understanding the Role of Exercise in Cancer Cachexia Therapy. / Hardee, Justin P.; Counts, Brittany R.; Carson, James.

In: American Journal of Lifestyle Medicine, Vol. 13, No. 1, 01.01.2019, p. 46-60.

Research output: Contribution to journalArticle

Hardee, Justin P. ; Counts, Brittany R. ; Carson, James. / Understanding the Role of Exercise in Cancer Cachexia Therapy. In: American Journal of Lifestyle Medicine. 2019 ; Vol. 13, No. 1. pp. 46-60.
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