Understanding the role of stromal fibroblasts in cancer progression

Manish Tripathi, Sandrine Billet, Neil A. Bhowmick

Research output: Contribution to journalReview article

49 Citations (Scopus)

Abstract

The major cellular components of tumor microenvironment, referred to as the cancer stroma, are composed of cancer-associated fibroblasts that support tumor epithelial growth, invasion and therapeutic resistance. Thus when we speak of developing therapies that address tumor heterogeneity it is not only a matter of different mutations within the tumor epithelia. While individual mutations in the stromal compartment are controversial, the heterogeneity in fibroblastic population in a single tumor is not up for debate. Cooperative interaction among heterotypic fibroblasts and tumor cells contribute to cancer progression. Therefore to tackle solid tumors, we need to understand its complex microenvironment. Here we review some seminal developments in the field of tumor microenvironment, mainly focusing on cancer-associated fibroblast.

Original languageEnglish (US)
Pages (from-to)231-235
Number of pages5
JournalCell Adhesion and Migration
Volume6
Issue number3
DOIs
StatePublished - Jan 1 2012
Externally publishedYes

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Fibroblasts
Neoplasms
Tumor Microenvironment
Mutation
Epithelium
Therapeutics
Growth
Population

All Science Journal Classification (ASJC) codes

  • Cellular and Molecular Neuroscience
  • Cell Biology

Cite this

Understanding the role of stromal fibroblasts in cancer progression. / Tripathi, Manish; Billet, Sandrine; Bhowmick, Neil A.

In: Cell Adhesion and Migration, Vol. 6, No. 3, 01.01.2012, p. 231-235.

Research output: Contribution to journalReview article

Tripathi, Manish ; Billet, Sandrine ; Bhowmick, Neil A. / Understanding the role of stromal fibroblasts in cancer progression. In: Cell Adhesion and Migration. 2012 ; Vol. 6, No. 3. pp. 231-235.
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