Unexpectedly low left ventricular voltage on ECG in hypertrophic cardiomyopathy

Karine Guerrier, Peace C. Madueme, John Jefferies, Jeffrey B. Anderson, David S. Spar, Timothy K. Knilans, Richard J. Czosek

Research output: Contribution to journalArticle

Abstract

Objective While late gadolinium enhancement (LGE) in paediatric patients with hypertrophic cardiomyopathy (HCM) is reported as similar to adults, the relationship between LGE and ECG findings in paediatric patients is unknown. We sought to evaluate the relationship between LGE on cardiac MRI and LV precordial voltage on ECG. Methods This was a retrospective analysis of paediatric patients with HCM aged 9-21 years with cardiac MRI and ECG completed within 60 days of each other. Demographic, MRI and ECG data were compared between patients with and without LGE. Maximal diastolic septal thickness, septal to free wall ratio and LGE presence were compared with LV precordial voltage (SV1, RV6 and SV1+RV6). Results This study included 37 patients (33 male). Mean age was 15.8±2.8 years. Mean maximal LV diastolic septal thickness was 22.1±7.9 mm. Mean septal to free wall ratio was 2.4±1.6 mm. LGE was present in 18 patients, with 16 isolated to the ventricular septum. Comparing patients with and without LGE, there was no difference in age (p=0.2) or body surface area (p=0.9). However, the presence of LGE was associated with significantly increased septal thickness ( p=0.03), yet decreased voltages in SV1 (p=0.005), RV6 (p=0.005) and SV1+RV6 (p=0.002) despite increased septal dimensions. Conclusions A significant inverse relationship exists between LGE presence and LV precordial voltage in this population. Unexpectedly low LV precordial voltages in patients with HCM may serve as a clinical surrogate marker for myocardial fibrosis and potential loss of viable myocardial tissue.

Original languageEnglish (US)
Pages (from-to)292-297
Number of pages6
JournalHeart
Volume102
Issue number4
DOIs
StatePublished - Feb 1 2016
Externally publishedYes

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Hypertrophic Cardiomyopathy
Gadolinium
Electrocardiography
Pediatrics
Biomarkers
Ventricular Septum
Body Surface Area
Fibrosis
Demography

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Guerrier, K., Madueme, P. C., Jefferies, J., Anderson, J. B., Spar, D. S., Knilans, T. K., & Czosek, R. J. (2016). Unexpectedly low left ventricular voltage on ECG in hypertrophic cardiomyopathy. Heart, 102(4), 292-297. https://doi.org/10.1136/heartjnl-2015-308633

Unexpectedly low left ventricular voltage on ECG in hypertrophic cardiomyopathy. / Guerrier, Karine; Madueme, Peace C.; Jefferies, John; Anderson, Jeffrey B.; Spar, David S.; Knilans, Timothy K.; Czosek, Richard J.

In: Heart, Vol. 102, No. 4, 01.02.2016, p. 292-297.

Research output: Contribution to journalArticle

Guerrier, K, Madueme, PC, Jefferies, J, Anderson, JB, Spar, DS, Knilans, TK & Czosek, RJ 2016, 'Unexpectedly low left ventricular voltage on ECG in hypertrophic cardiomyopathy', Heart, vol. 102, no. 4, pp. 292-297. https://doi.org/10.1136/heartjnl-2015-308633
Guerrier K, Madueme PC, Jefferies J, Anderson JB, Spar DS, Knilans TK et al. Unexpectedly low left ventricular voltage on ECG in hypertrophic cardiomyopathy. Heart. 2016 Feb 1;102(4):292-297. https://doi.org/10.1136/heartjnl-2015-308633
Guerrier, Karine ; Madueme, Peace C. ; Jefferies, John ; Anderson, Jeffrey B. ; Spar, David S. ; Knilans, Timothy K. ; Czosek, Richard J. / Unexpectedly low left ventricular voltage on ECG in hypertrophic cardiomyopathy. In: Heart. 2016 ; Vol. 102, No. 4. pp. 292-297.
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abstract = "Objective While late gadolinium enhancement (LGE) in paediatric patients with hypertrophic cardiomyopathy (HCM) is reported as similar to adults, the relationship between LGE and ECG findings in paediatric patients is unknown. We sought to evaluate the relationship between LGE on cardiac MRI and LV precordial voltage on ECG. Methods This was a retrospective analysis of paediatric patients with HCM aged 9-21 years with cardiac MRI and ECG completed within 60 days of each other. Demographic, MRI and ECG data were compared between patients with and without LGE. Maximal diastolic septal thickness, septal to free wall ratio and LGE presence were compared with LV precordial voltage (SV1, RV6 and SV1+RV6). Results This study included 37 patients (33 male). Mean age was 15.8±2.8 years. Mean maximal LV diastolic septal thickness was 22.1±7.9 mm. Mean septal to free wall ratio was 2.4±1.6 mm. LGE was present in 18 patients, with 16 isolated to the ventricular septum. Comparing patients with and without LGE, there was no difference in age (p=0.2) or body surface area (p=0.9). However, the presence of LGE was associated with significantly increased septal thickness ( p=0.03), yet decreased voltages in SV1 (p=0.005), RV6 (p=0.005) and SV1+RV6 (p=0.002) despite increased septal dimensions. Conclusions A significant inverse relationship exists between LGE presence and LV precordial voltage in this population. Unexpectedly low LV precordial voltages in patients with HCM may serve as a clinical surrogate marker for myocardial fibrosis and potential loss of viable myocardial tissue.",
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AU - Guerrier, Karine

AU - Madueme, Peace C.

AU - Jefferies, John

AU - Anderson, Jeffrey B.

AU - Spar, David S.

AU - Knilans, Timothy K.

AU - Czosek, Richard J.

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N2 - Objective While late gadolinium enhancement (LGE) in paediatric patients with hypertrophic cardiomyopathy (HCM) is reported as similar to adults, the relationship between LGE and ECG findings in paediatric patients is unknown. We sought to evaluate the relationship between LGE on cardiac MRI and LV precordial voltage on ECG. Methods This was a retrospective analysis of paediatric patients with HCM aged 9-21 years with cardiac MRI and ECG completed within 60 days of each other. Demographic, MRI and ECG data were compared between patients with and without LGE. Maximal diastolic septal thickness, septal to free wall ratio and LGE presence were compared with LV precordial voltage (SV1, RV6 and SV1+RV6). Results This study included 37 patients (33 male). Mean age was 15.8±2.8 years. Mean maximal LV diastolic septal thickness was 22.1±7.9 mm. Mean septal to free wall ratio was 2.4±1.6 mm. LGE was present in 18 patients, with 16 isolated to the ventricular septum. Comparing patients with and without LGE, there was no difference in age (p=0.2) or body surface area (p=0.9). However, the presence of LGE was associated with significantly increased septal thickness ( p=0.03), yet decreased voltages in SV1 (p=0.005), RV6 (p=0.005) and SV1+RV6 (p=0.002) despite increased septal dimensions. Conclusions A significant inverse relationship exists between LGE presence and LV precordial voltage in this population. Unexpectedly low LV precordial voltages in patients with HCM may serve as a clinical surrogate marker for myocardial fibrosis and potential loss of viable myocardial tissue.

AB - Objective While late gadolinium enhancement (LGE) in paediatric patients with hypertrophic cardiomyopathy (HCM) is reported as similar to adults, the relationship between LGE and ECG findings in paediatric patients is unknown. We sought to evaluate the relationship between LGE on cardiac MRI and LV precordial voltage on ECG. Methods This was a retrospective analysis of paediatric patients with HCM aged 9-21 years with cardiac MRI and ECG completed within 60 days of each other. Demographic, MRI and ECG data were compared between patients with and without LGE. Maximal diastolic septal thickness, septal to free wall ratio and LGE presence were compared with LV precordial voltage (SV1, RV6 and SV1+RV6). Results This study included 37 patients (33 male). Mean age was 15.8±2.8 years. Mean maximal LV diastolic septal thickness was 22.1±7.9 mm. Mean septal to free wall ratio was 2.4±1.6 mm. LGE was present in 18 patients, with 16 isolated to the ventricular septum. Comparing patients with and without LGE, there was no difference in age (p=0.2) or body surface area (p=0.9). However, the presence of LGE was associated with significantly increased septal thickness ( p=0.03), yet decreased voltages in SV1 (p=0.005), RV6 (p=0.005) and SV1+RV6 (p=0.002) despite increased septal dimensions. Conclusions A significant inverse relationship exists between LGE presence and LV precordial voltage in this population. Unexpectedly low LV precordial voltages in patients with HCM may serve as a clinical surrogate marker for myocardial fibrosis and potential loss of viable myocardial tissue.

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