Unexplained elevated maternal serum α-fetoprotein is not predictive of adverse perinatal outcome in an indigent urban population

Owen Phillips, Joe Leigh Simpson, Cynthia D. Morgan, Richard N. Andersen, Lee P. Shulman, Carole M. Meyers, Baha Sibai, David C. Shaver, Elizabeth Tolley, Sherman Elias

Research output: Contribution to journalArticle

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Abstract

Objective: The null hypothesis of this study is that in an urban, indigent obstetric population at high risk for adverse perinatal outcome, unexplained elevations of maternal serum a-fetoprotein are not an additional predictor of adverse perinatal outcome. Study Design: Perinatal outcomes of 72 patients from a clinic for indigent patients with unexplained elevated maternal serum a-fetoprotein levels were compared with those of matched controls from the same population with normal maternal serum a-fetoprotein levels. Subjects and controls were matched for age, race, parity, and presence or absence of Hollister risk factors. The frequency of adverse perinatal outcome in the two groups was subjected to matched-pair χ2 analysis. Results: Adverse perinatal outcome occurred in 38.9% (28 of 72) of subjects with unexplained elevated maternal serum α-fetoprotein levels ≥2.5 multiples of the median, compared with 31.9% (23 of 72) of controls with normal maternal serum a-fetoprotein levels (p = 0.5). No statistically significant difference in adverse perinatal outcomes was found. Conclusions: Elevated maternal serum α-fetoprotein levels offer little if any additional predictive value for adverse perinatal outcome in populations already at high risk for such outcomes on the basis of obstetric or socioeconomic criteria.

Original languageEnglish (US)
Pages (from-to)978-982
Number of pages5
JournalAmerican Journal of Obstetrics and Gynecology
Volume166
Issue number3
DOIs
StatePublished - Jan 1 1992

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Fetal Proteins
Urban Population
Poverty
Mothers
Serum
Obstetrics
Matched-Pair Analysis
Parity
Population

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynecology

Cite this

Unexplained elevated maternal serum α-fetoprotein is not predictive of adverse perinatal outcome in an indigent urban population. / Phillips, Owen; Simpson, Joe Leigh; Morgan, Cynthia D.; Andersen, Richard N.; Shulman, Lee P.; Meyers, Carole M.; Sibai, Baha; Shaver, David C.; Tolley, Elizabeth; Elias, Sherman.

In: American Journal of Obstetrics and Gynecology, Vol. 166, No. 3, 01.01.1992, p. 978-982.

Research output: Contribution to journalArticle

Phillips, Owen ; Simpson, Joe Leigh ; Morgan, Cynthia D. ; Andersen, Richard N. ; Shulman, Lee P. ; Meyers, Carole M. ; Sibai, Baha ; Shaver, David C. ; Tolley, Elizabeth ; Elias, Sherman. / Unexplained elevated maternal serum α-fetoprotein is not predictive of adverse perinatal outcome in an indigent urban population. In: American Journal of Obstetrics and Gynecology. 1992 ; Vol. 166, No. 3. pp. 978-982.
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abstract = "Objective: The null hypothesis of this study is that in an urban, indigent obstetric population at high risk for adverse perinatal outcome, unexplained elevations of maternal serum a-fetoprotein are not an additional predictor of adverse perinatal outcome. Study Design: Perinatal outcomes of 72 patients from a clinic for indigent patients with unexplained elevated maternal serum a-fetoprotein levels were compared with those of matched controls from the same population with normal maternal serum a-fetoprotein levels. Subjects and controls were matched for age, race, parity, and presence or absence of Hollister risk factors. The frequency of adverse perinatal outcome in the two groups was subjected to matched-pair χ2 analysis. Results: Adverse perinatal outcome occurred in 38.9{\%} (28 of 72) of subjects with unexplained elevated maternal serum α-fetoprotein levels ≥2.5 multiples of the median, compared with 31.9{\%} (23 of 72) of controls with normal maternal serum a-fetoprotein levels (p = 0.5). No statistically significant difference in adverse perinatal outcomes was found. Conclusions: Elevated maternal serum α-fetoprotein levels offer little if any additional predictive value for adverse perinatal outcome in populations already at high risk for such outcomes on the basis of obstetric or socioeconomic criteria.",
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AU - Shulman, Lee P.

AU - Meyers, Carole M.

AU - Sibai, Baha

AU - Shaver, David C.

AU - Tolley, Elizabeth

AU - Elias, Sherman

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N2 - Objective: The null hypothesis of this study is that in an urban, indigent obstetric population at high risk for adverse perinatal outcome, unexplained elevations of maternal serum a-fetoprotein are not an additional predictor of adverse perinatal outcome. Study Design: Perinatal outcomes of 72 patients from a clinic for indigent patients with unexplained elevated maternal serum a-fetoprotein levels were compared with those of matched controls from the same population with normal maternal serum a-fetoprotein levels. Subjects and controls were matched for age, race, parity, and presence or absence of Hollister risk factors. The frequency of adverse perinatal outcome in the two groups was subjected to matched-pair χ2 analysis. Results: Adverse perinatal outcome occurred in 38.9% (28 of 72) of subjects with unexplained elevated maternal serum α-fetoprotein levels ≥2.5 multiples of the median, compared with 31.9% (23 of 72) of controls with normal maternal serum a-fetoprotein levels (p = 0.5). No statistically significant difference in adverse perinatal outcomes was found. Conclusions: Elevated maternal serum α-fetoprotein levels offer little if any additional predictive value for adverse perinatal outcome in populations already at high risk for such outcomes on the basis of obstetric or socioeconomic criteria.

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