Unique and common protective epitopes among different serotypes of group A streptococcal M proteins defined with hybridoma antibodies

James Dale, E. H. Beachey

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

A set of 4 monoclonal antibodies was produced against a highly purified pepsin extract of type 5 streptococcal M protein. Three of the 4 antibodies cross-reacted with purified M proteins from heterologous serotypes and opsonized the respective heterologous organisms. Our studies suggest that monoclonal antibodies may be useful in identifying subpeptides of various M proteins containing common, protective epitopes that are capable of evoking antibodies that would protect against several different potentially 'rheumatogenic' serotypes.

Original languageEnglish (US)
Pages (from-to)267-269
Number of pages3
JournalInfection and Immunity
Volume46
Issue number1
StatePublished - Jan 1 1984
Externally publishedYes

Fingerprint

Hybridomas
Epitopes
Monoclonal Antibodies
Antibodies
Pepsin A
Proteins
streptococcal M protein
Serogroup

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

Cite this

Unique and common protective epitopes among different serotypes of group A streptococcal M proteins defined with hybridoma antibodies. / Dale, James; Beachey, E. H.

In: Infection and Immunity, Vol. 46, No. 1, 01.01.1984, p. 267-269.

Research output: Contribution to journalArticle

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